Abstract: The floristic elements of the study area comprises 240 species. The majority of these species (238) belong to Angiospermae, the other two species (Mushroom and Chara) are belonging to Gymnospermae. A total number of species 238 Angiospermae belonging to 54 families and 155 genera. The most represented families were Graminae (4.29%), Leguminosae (11.76%), Compositae (9.2%), Cruciferae (4.6%), Zygophyllaceae (4.2%), Euphorbiaceae (3.4%), Boraginaceae (3.4%) and Asclepidaceae (2.9%). Vegetation analysis in the south eastern part of the southern eastern desert of Egypt indicates the dominance of Polycarpea repens, Zygophyllum simplex, Triraphis pumilio, Astragalus eremophilus, Fagonia indica, Aizoon canariense, Caylusea hexagyna, Acacia tortilis subsp. tortilis, Aerva javanica, Aristida mutabilis, Asphodelus tenuifolius and Panicum turgidum. Seven vegetation clusters are recognized after the application of the two-way indicator species analysis (Twinspan). These clusters are named after the dominant species as follows: Indigofera spinosa-Cocculus pendulus- Peristrophe paniculata-Cucumis prophetarum-Convolvulus hystrix, Chenopodium murale, Zygophyllum simplex, Coelachyrum brevifolium-Cleome amblyocarpa, Salsola imbricata, Polycarpea robbairea and Heliotropium bacciferum. Among the estimated soil variables in this study, pH and HCO3 are important in characterizing the vegetation clusters.