Characterization and Biological Screening of a Triterpenoid from Nymphoides cristatum
Abstract:
A triterpenoid, Bet-20(29)-en-3-ol-28-oic acid (1) was isolated from the ethyl acetate
extract of Nymphoides cristatum (Roxb.) O.kuntze and its structure was elucidated on the
basis of spectral evidences. This is the first report of isolation of this compound from this
plant. The compound was screened for antimicrobial activity against a number of
pathogenic bacteria and fungi and the cytotoxic activity by brine shrimp lethality bioassay.
The test agent exhibited significant antimicrobial activity against most of the bacteria and
fungi. The minimum inhibitory concentration (MIC) of the test agent determined against
Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella sonnei was found to be 64,
128, 64 and 32 μg/ml respectively. The compound also showed prominent cytotoxic
activity. The LC50 (median lethal concentration) was 15.39 μg/ml. 50.
How to cite this article
Atiqur Rahaman, Abu Sayeed , Anwarul Islam , Dulaly Chowdhury , Golam Sadik and G. R. M. Astaq Mohal Khan , 2002. Characterization and Biological Screening of a Triterpenoid from Nymphoides cristatum. Journal of Biological Sciences, 2: 46-48.
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Direct Link
Rahman, A., A. Sayeed, A. Islam and G.R.M. Astaq Mohal, 2001. Antimicrobial activity and cytotoxicity of Nymphoides cristatum (Roxb.) O. kuntze. Fitoterapia,
Rahman, A., 2000. Phytochemical and biological studies on Nymphoides cristatum (Roxb.) O. kuntze. M.Sc. Thesis, Department of Applied Chemistry and Chemical Technology, Rajshahi University, Bangladesh.
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