Abstract: In this study, using elastic-plastic fiber unit model for a continuous beam bridge structure and foundation to analyses the nonlinear seismic response of pier and pile foundation considering pile-soil interaction and the different types of seismic wave on the pile foundation and the pier’ dynamic response, focusing on the development of plastic zone and dynamic response of structure under different pile-pier reinforcement ration conditions. The results show that, with the pile pier reinforcement ratio increases, the response plasticity of pile and pier show a different trend; so pile-pier reinforcement ration is an important factor of dynamic characteristics for the bridge pier supported by group piles system; the pier reinforcement ratio not only impact on development of the plastic zone of the pier but also impact on the pile. In addition, different types of seismic waves on the structure are different, the long-period seismic waves maximum, followed by inland direct seismic waves, plate boundary seismic wave minimum.