Abstract: Faced with the changing economic pattern in our country, there have been qualitative changes in its original nature and form. Taking sustainable development as the main principle, under the guidance of second spatial creation theory, this study combines the original industrial plants, historic districts and old business buildings with the requirements of the function and form space development in the new period, proposes the second design concept for heterogeneous space and describes several characteristic spatial patterns from the changes of space function, the elements of landscape structure and other aspects, thus realizing the development and regeneration of unused or abandoned space forms in the new period.