Abstract: As the most chemical processes that we need to analyze and models are becoming more complex in terms of their interdependencies, conventional modeling methods may not be as applicable as they once were. Agent is now being considered as the most effective tool to design and build complex and distributed system. Agent-based architecture provides additional robustness, scalability, flexibility and is particularly appropriate for problems with a dynamic, uncertain and distributed nature. In this paper, a framework of agent-based modeling for chemical process is illustrated. The chemical process characteristics are classified systematically. The modeling elements, as well as semantics and graphical representations for each element are defined and described. And two cases in different scenarios of chemical process industry, including tank-level system and rectification system, are presented in the following section. Finally, several future research directions toward the successful deployment of agent technology in chemical process industry are discussed.