Abstract: Information and Communication Technologies (ICT) have generally been adopted and applied in organizations. Furthermore, they deeply affect not only organizational operations but also industrial integration/cooperation. Considering the influence of ICT on organizational/inter-organizational structures helps to present a more detailed picture of future organizational or inter-organizational development. Frameworks and models of structural design by mintzberg, malone, yates and benjamin, barrett and konsynski and lucas and baroudi were selected and discussed in this study. In addition, this research incorporates studies on the influence of ICT on organizational structure by Rockart and Short, Palmer, Lipnack and Stamps and Shih. Through the in-depth use of ICT, the ultimate virtualization may lead to a new form of organizational structure. This study proposes a flexible synapse network in an organization and an inter-organization value network that incorporates not only conventional organizational design parameters but also ICT-driven innovations. This structure is characterized by a side-by-side coordination relationship between organizational functions, the blurring of boundaries and partnerships with other organizations through agents.