Abstract: The bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), has experienced an extraordinary resurgence in recent years, the reasons for which remain poorly understood. Several studies have focused on determining the susceptibility of bed bug populations to insecticides. However, behavioral responses of bed bug to insecticide residues could influence their efficacy. Understanding the population dynamic and patterns of dispersal may prove critical to the development of effective control strategies. In this study, the two mathematical models for the dynamics of bed bug infestation in a residential community were developed and in which houses are considered to be patches in one of three states: susceptible, infested, or treated. The basic reproduction number and equilibria of the two models are discussed. The heterogeneous houses model was used to assess the effect of different control strategies on house infestation. The empirical results show that spraying only bad houses is more beneficial than spraying the whole community while using the same treatment rate.