Abstract: A two months of toxologic pathology study of cypermethrin in domestic pigeons by oral intubation were done. The study was done at three dosage levels as: low (0.25 ml), intermediate (0.50 ml) and high (0.75 ml) with untreated control as fourth group. Histopathological changes found that in the heart areas of vacuolation of myocardial muscle cells were noticed in all treated groups, some with foci of fat cells between myocardial muscles cells. While, in the liver there were many pathological changes like; a minimal diffuse vacuolation of hepatocytes and several foci of inflammatory cells mainly mononuclear, other with periportal fibrosis and septal fibrosis and moderate diffuse vacuolation of hepatocytes, also, granuloma with multinucleate giant cells and foci of mononuclear cells one with microgranuloma and a suppurative granuloma and foci of mononuclear cells. In spleen’s pigeons found atrophic lymphoid tissue, some with perifollicular fibrosis, other with a minimal atrophic of white palp lymphoid tissue. In pancreas a vacuolation of islets of langerhans were noticed in all treated groups. In lungs with low, intermediate and high dose the pathological changes were found an emphysema and congestion, some with foamy alveolar macrophages. In low dose of cypermethrin there was no pathological changes in kidney, but in intermediate and high dose a dilated cortical tubules were found. In brain at all treated groups found a normal without any pathological changes. The sciatic nerve in pigeons with low and intermediate dose of cypermethrin found an occasional degenerate vacuolated nerve fibers, prominent shwann cells. While, in high dose a several degenerate vacuolated nerve fibers were noticed. An occasional degenerate vacuolated nerve fibers were found in spinal cord of pigeons with low dose, while, in intermediate dose a few degenerate vacuolated nerve fibers. In high dose a numerous degenerate vacuolated nerve fibers were found.