The Anti-inflammatory Activity of the Foeniculum vulgare L. Essential Oil and Investigation of its Median Lethal Dose in Rats and Mice
Abstract:
The aim of this study was to gas chromatographic analysis of extract of Foeniculum vulgare L. essential oil and to investigate its median lethal dose (LD50) and possible anti-inflammatory effects. The composition of the essential oil was as follows: 74.8% (E)-anethole, 11.1% limonene, 4.7% methyl chavicol, 2.5% fenchone and 1.3% α-pinene. The LD50 dose was found to be 1.038 mL kg-1. The essential oil of Foeniculum vulgare L. was investigated the model of carrageenan induced rat paw edema and it had an anti-inflammatory effect matching to that of etodolac at 0.050 and 0.200 mL kg-1 doses.
How to cite this article
Hanefi Ozbek , 2005. The Anti-inflammatory Activity of the Foeniculum vulgare L. Essential Oil and Investigation of its Median Lethal Dose in Rats and Mice. International Journal of Pharmacology, 1: 329-331.
REFERENCES
Simandi, B., A. Deak, E. Ronyai, G. Yanxiang and T. Veress et al., 1999. Supercritical carbon dioxide extraction and fractionation of fennel oil. J. Agric. Food Chem., 47: 1635-1640.
Direct Link
Ozbek, H., 2002. Investigation of the level of the lethal dose 50 and the hypoglycemic effect of Foeniculum vulgare Mill. Fruit essential oil extract in healthy and diabetic mice. Van Tip Derg., 9: 98-103.
Ozbek, H., S. Urao, H. Dulger, I. Bayram, G. Tuncer and A. Ozturk, 2003. Hepatoprotective effect of Foeniculum vulgare essential oil. Fitoterapia, 74: 317-319.
CrossRef Direct Link
Ozbek, H., S. Ugras, I. Bayram, I. Uygan and E. Erdogan, 2004. Hepatoprotective effect of Foeniculum vulgare essential oil: A carbon-tetrachloride induced liver fibrosis model in rats. Scand. J. Lab. Anim. Sci., 31: 9-17.
Merkes, K., 1980. Drogen mit atherischem Ol (XVI) Foeniculum vulgare Miller-fenchel. PTA Repetitorium, 12: 45-48.
Forster, H.B., H. Niklas and S. Lutz, 1980. Antispasmodic effects of some medicinal plants. Planta Med., 40: 309-319.
CrossRef Direct Link
Forster, H.B., 1983. Spasmolytische wirkung pflanzhlicher carminativa. Z Aliment Med., 59: 1327-1333.
Litchfield, Jr. J.T. and F. Wilcoxon, 1949. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther., 96: 99-113.
PubMed Direct Link
Abdel-Barry, J.A., M.H.H. Al-Hakiem and I.A. Abdel-Hassan, 1997. Acute intraperitoneal toxicity (LD50) and target organ effects of aqueous extract of Trigonella foenum-graecum leaf in the mouse. Basrah J. Sci. Sect. B Biol., 58: 58-65.
Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Exp. Biol. Med., 111: 544-547.
CrossRef PubMed Direct Link
Rimbau, V., C. Cerdan, R. Vila and J. Iglesias, 1999. Antiinflammatory activity of some extracts from plants used in the traditional medicine of North-African countries. Phytother. Res., 13: 128-132.
PubMed Direct Link
Inoue, K., A. Motonaga, T. Nishimura, M. Yokota, N. Miki et al., 1991. Mechanism of anti-inflammatory action of etodolac. Arzneimittelforschung, 41: 235-239.
Kouadio, F., C. Kanko and M. Juge, 2000. Analgesic and anti-inflammatory activities of an extract from Parkia biglobosa used in traditional medicine in the Ivory Coast. Pytother. Res., 14: 635-637.
Souza, M.C., A.C. Siani, M.F. Ramos, O.J. Menezes-de-Lima and M.G. Henriques, 2003. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Pharmazie, 58: 582-586.
PubMed Direct Link
Lorente, I., M.A. Ocete, A. Zarzuelo, M.M. Cabo and J. Jimenez, 1989. Bioactivity of the essential oil of Bupleurum fruticosum. J. Nat. Prod., 52: 267-272.
Martin, S., E. Padilla, M.A. Ocete, J. Galvez, J. Jimenez and A. Zarzuelo, 1993. Anti-inflammatory activity of the essential oil of Bupleurum fruticescens. Planta Med., 59: 533-536.
Akgul, A., 1993. Baharat Bilimi and Teknolojisi. 1st Edn., Gida Teknolojisi Dernei Yayinlari, Ankara, Turkey, pp: 96-98
Hansel, R., K. Keller and H. Rimpler, 1993. Foeniculum 5, Hagers Hanbuch der Pharmazeutischen, Praxis. 5th Edn., Springer, New York, pp: 156-181
Pamuk, H.A., 1998. Oifali Bitkiler Ansiklopedisi. 1st Edn., Pamuk Yayincilik ve Matbaacilik, 1stanbul, Turkey, pp: 272-543
© Science Alert. All Rights Reserved