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International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 1 | Page No.: 25-28
DOI: 10.3923/ijp.2005.25.28
Pharmacokinetics and Tolerance of Thiamphenicol in Camels and Sheep
Mohammed H. Al-Nazawi

Abstract: The pharmacokinetics and tolerance of thiamphenicol (TAP) were investigated in camel and sheep following administration of intravenous dose of 20 mg kg -1 body weight. The disposition kinetic of TAP in camel and sheep showed a biexponential profile with elimination half-live of 2.11 h for camel and 1.5 h for sheep and volume of distribution of 1.1 L kg -1 for camel and 0.90 L kg -1 for sheep indicating extensive tissue penetration which is consistent with TAP lipophilicity. The drug administered at a dose of 40 mg kg -1 to camel and sheep produced no changes in haematological and plasma biochemical parameters suggesting that both species can tolerate higher doses of the drug.

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Mohammed H. Al-Nazawi , 2005. Pharmacokinetics and Tolerance of Thiamphenicol in Camels and Sheep. International Journal of Pharmacology, 1: 25-28.

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