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Research Article

Laser Acupuncture Therapy: An Alternative Treatment to Mitigate the Menopausal Hot Flashes Symptom

Ahmed Elsadeek Radwan, Mohamed Amr Hussein Elnoury and Sherif Fathi El Mekkawi
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Background and objective: Hot flashes symptoms are considered as the maximum popular menopausal signs that triggered scientists to look for other therapeutic methods with super-performance such as laser acupuncture. So, the main objective of the research study was to evaluate the feasibility of laser acupuncture for reducing hot flashes and offering an alternative therapy. Materials and Methods: The research study was performed on 120 menopausal cases with an age range of 40-60 years old with the continuous suffering of hot flushes. Participants have been divided into different groups as follows: (a) Laser acupuncture, (b) Oral tibolone 2.5 mg/day therapy, (c) Combined therapy and (d) No interventions. Serum FSH, LH and E2 levels have been measured before and after application management. Results: Treatment with laser acupuncture and medical therapy using oral tibolone 2.5 mg/day significantly improved the menopausal disorders with p<0.05 and p<0.03, respectively. Additionally, the combined therapy group showed higher significant decrease in the rate and number of hot flushes with p<0.001. Concerning the hormonal changes; on one side, medical drug therapy and combined therapy revealed higher significant amelioration in the FSH hormone than laser therapy; on the other side, laser therapy did not show significant differences in LH and E2. Conclusion: laser acupuncture therapy considered an efficient alternative therapy for reduction of postmenopausal hot flushes and amelioration of the hormonal disorders.

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Ahmed Elsadeek Radwan, Mohamed Amr Hussein Elnoury and Sherif Fathi El Mekkawi, 2020. Laser Acupuncture Therapy: An Alternative Treatment to Mitigate the Menopausal Hot Flashes Symptom. Research Journal of Obstetrics and Gynecology, 13: 14-19.

DOI: 10.3923/rjog.2020.14.19

Copyright: © 2020. This is an open access article distributed under the terms of the creative commons attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.


The transitional phases of amenorrhea and premenopause1-2 trigger a change in the ovarian function and hormonal disturbance3 and followed by post menopause after the last menstrual period1. The menopause is accompanied by hormonal disturbances and physiological down-regulation of ovarian hormone secretion1,4-7.

Menopause is a phase with hormonal disorders that can occur naturally through the aging process between 40 and 58 years of age8 or artificially from ovarian surgical removal, radiotherapy and chemotherapy9,10. All these natural menopausal phases induce vasomotor and vaginal symptoms, urinary stress incontinence, sexual dysfunction, mood disturbance and depression and cognitive difficulties11-13.

Moreover, the prominent subsequent vasomotor symptomatic disorders are the formation of hot flushes as temporary and recurring episodes of heat sensation and reddishness linked with sweating, increased skin temperature in the face, neck, head and breast followed by cutaneous vasodilation signs10,14-17. Additionally, these flashes are considered as behavioral brain reflex to the decreased and fluctuated hormonal secretions such as estrogen and gonadotropin that triggering in stable thermo-regulation mechanisms and temperature homeostasis11,18-21.

So, acupuncture using needles into certain points in the body is considered as the popular applied type of complementary medicines with different therapeutic ameliorative therapies22. Additionally, manual pressure (acupressure), small electric currents through the inserted needles (electro-acupuncture) and lasers can also stimulate these points.

Approximately half of women experiencing menopause associated symptoms use complementary and alternative medicine therapy for managing their menopausal symptoms15. Further, laser acupuncture has been defined as the new local stimulation procedure for conventional acupuncture points with low-intensity and non-thermal irradiation23 in order to re-establish the energy flow balance and depletion24. Cohen et al.25 used laser specific acupuncture points for menopausal complications through the kidney qi and Yin energy in order to balance, nourish the heart and quieten the spirit and generally the mental and behavioral disorders. So, the originality of the present work lies in the fact that laser acupuncture could be considered as a new technology that combines the advantages of traditional Chinese acupuncture with needles and modern laser medicine depending upon the oscillating energy enhancement of the same acupuncture points.

The current study aimed to assess the activity and the impact of the specific laser acupuncture points in the postmenopausal complications such as the number and intensity of hot flashes and the disturbances in the hormonal regulation in comparison to the drug treatment and no-intervention.


Randomized and double-blinded 120 menopausal female subjects aged in the range of 40-60 years using the kupperman menopausal index (KMI) equal or more than 15, have been recruited randomly at the National Institute of Laser Medical Center, Cairo University and Ain Shams University maternity hospital, Cairo, Suez Health Insurance Hospital, Suez. The study was performed for 6 months from November, 2015 to end of April, 2016. All analysis and sample selection were carried out under the ethical patients committee of the Suez Health Insurance Hospital, Suez. Ethical approval and permission to conduct the study were obtained from the local ethics committee No. #2019/01/1236 and the administration of the study was based on international ethical guidelines. Informed consent had been signed by each patient before they participated in the study.

The study subjects were categorized into 4 research groups with 30 individuals in each group as follow: (A) Treated with laser acupuncture, (B) Treated with oral tibolone 2.5 mg/day, (C) Combined therapy with Laser acupuncture and oral tibolone 2.5 mg/day, (D) Control group could not receive conventional therapy (self-care group). Moreover, all medical assessment parameters have been evaluated through a blind evaluative before and post treatment.

Primary outcome assessment: Change in the moderate to the severe mean number of hot flushes/week through a combination of the Mann Whitney Values (MWV) of the kupperman menopausal index (KMI) and the recurrence of counteractive events by the end of treatment. Secondary outcome measurements include menopausal symptoms and quality of life, Hot flush weekly weighted score, kupperman menopausal index (KMI), assessments of hazardous events, physical examinations, urogenital symptoms, laboratory investigations (FSH, LH, Estradiol).

The laser acupuncture therapy was performed through using the 6 acupuncture points (Sanyinjiao (sp6), Hegu (Li4), Quchi (Li11), Fengchi (GB20), Guanyuan (CV 4) and Fuliu (Ki7)) according protocol of Cohen25 for each woman 3 sessions/week as shown as in Fig. 1a-d. Moreover, the continuous follow-up time was necessary in order to record the full result outcomes of laser therapy as the treatment of choice for menopausal women hot flushes.

Fig. 1(a-d):
Laser acupuncture points used in the study
Main laser acupuncture points treated in the study: Sanyinjiao (sp 6), Hegu (Li4), Quchi (Li11), Fengchi (GB 20), Guanyuan (CV4) and Fuliu (Ki7))

Laser acupuncture procedures have been carried out using Laser Model Giotto, classic I (LED SpA, Italy). Each point was stimulated with infrared laser diode with stimulation time for 90 sec using 904 nm wavelength and strength, power of 5 MW.

The head of the machine was targeted perpendicularly with direct contact to each point. Additionally, the conventional therapy group with traditional medication was prescribed with oral Livial (Tibolone, 2.5 mg/tablet) for 6 consecutive weeks. Enzyme-linked immunosorbent assay (ELISA) used for the estimation of the levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and the levels of E2. All these parameters have been measured 1 day before the end of the treatment, according the Health Labs kit protocol.

Statistical analysis: Statistical analysis was performed by using the software program Statistical Package for the Social Sciences (SPSS 15.0, Chicago, IL, USA). Participants’ demographic information and levels of major measured variables were analyzed by descriptive statistics. Means and standard (Mean±SD) deviations of the clinical indices were calculated, after which the evaluation between groups was compared using a Student’s t-test. Two-way ANOVA analysis was used to study the repeated measures for the clinical indices across the 6 data collection points (treatments for 6 weeks, followed-up evaluation twice/week) and value of p<0.05 was considered as statistically significant for the above statistical analysis.


Effect of Laser therapy on hot flashes episodes: The present clinical research study has imposed the role of the laser acupuncture therapy in decreasing the hot flushes rate and severity among post-menopausal women with hot flushes history.

Fig. 2:
Effect of laser and tibolone 2.5 mg treatments on the hot flashes rate
Values are expressed as Mean±SE

Fig. 3:
Effect of laser and tibolone 2.5 mg treatments on the serum level of follicle-stimulating hormone (FSH) among menopausal women
Values are expressed as Mean±SE

Fig. 4:
Effect of laser and tibolone 2.5 mg treatments on the serum level of luteinizing hormone (LH) among menopausal women
Values are expressed as Mean±SE

Fig. 5:
Effect of different treatments on the serum level of estrogen hormone (E2) among menopausal women
Values are expressed as Mean±SE

Results revealed significant improvement for post-menopausal hot flashes disorders between before and after the laser acupuncture and medical therapy using oral tibolone 2.5 mg/day with p<0.05 and p<0.03, respectively as shown in Fig. 2. While the integrated combined therapy group treated with laser and drug treatment enhanced significant decrease in the rate and number of hot flushes suffering behavior with p<0.001 as shown in Fig. 2. Moreover, the control group with no-intervention treatment did not show significant change before and after treatment of the laser. The indicated laser acupuncture points showed highly significant amelioration in the number of hot flashes among groups as shown in Fig. 2.

Effect of laser acupuncture therapy for hormonal disorders: Concerning the hormonal changes; on one side, medical drug therapy, combined therapy groups revealed higher significant amelioration in the FSH hormone with value p<0.001 than laser therapy with value p<0.05 as illustrated in Fig. 3, on the other side, oral drug treatment and combined therapy showed significant decreased LH p<0.001 as shown in Fig. 4 and increased in E2 as shown in Fig. 5. No significant effect of laser therapy treatment for LH as shown in Fig. 4.


Hot flashes as a result of the menopausal complications triggered women to look for natural remedies and medications for relief from its consequents such as using conventional medicine such as Chinese needle26. Furthermore, many menopausal women would prefer other hormonal replacement or even local estrogen therapies. Manson et al.27 stated that menopausal women suffering from vaginal atrophy receiving treatment, urogenital atrophy are the only symptom that will experience at some level28.

The present study is considered a modest contribution to the impact of the laser treatment for post-menopause symptoms such as hot flashes symptoms. Therefore, the present study demonstrated the significant role of laser therapy in amelioration of the hot flushes complications triggered by menopause. Additionally, the combined treatment of laser and drug medication was better than each therapy separately. Furthermore, our results were in agreement with Gaspar et al.29, who has explored that laser therapy was better than hormonal therapy with consequent reducing of some common post-menopausal symptoms.

Additionally, on one side, the present study showed that laser therapy triggered sufficient amelioration in the endogenous hormones FSH, while, normal medication and combined therapy induced highly significant improvement in both LH and E2 hormone levels. On the other side, laser treatment did not induce changes in the hormonal levels of LH and E2. The present study results was in agreement with Gaspar et al.29 showed that laser treatment can be used in patients who have estrogen contraindicated with no contraindications and no known complications. Qu et al.30 showed sufficient improvement in some physiological parameters such as serum follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and prolactin without a change in estrogen among the laser therapy patient. Moreover, the current study revealed that tibolone therapy has the ability to relief climacteric complaints of hot flashes. The points stimulate the blood flow to the vaginal tissue and regenerate vaginal cells to invigorate collagen development. Additionally, renewed collagen development helps to combat the symptoms of vaginal atrophy and hormonal impairments which can help reduction of the painful symptoms like rapid episodes of flushing/reddening of the skin and sensations of heat and sweating30.

Tibolone showed statistically significant difference not only in the rate and severity of hot flushes before and after treatment, but also in the serum levels of FSH, LH and E2. These findings are in agreement with a prior research study displaying that tibolone exerts encouraging effects on climacteric symptoms among sever conditions of menopause patients4. Moreover, the particular attention for Tibolone depending upon its known activity mechanism as it enhances the estrogen receptor (ER) and both progesterone and androgen receptors through its metabolic products 3α and 3β-hydroxy and 3-Quito-Δ4, respectively6,31,32. The Er:YAG laser therapy showed it to be an excellent alternative for vaginal atrophy symptoms management, in post-gynecological cancer patients as well as in menopause women33.

The present study used some of the acupuncture points common for treatment with a needle with traditional Chinese Medical therapy. The present study used specific acupuncture points that in a agreement with the acupuncture points used by Scheid34, who considered that kidney deficiency triggering the menopausal symptoms, therefore, Ki point is considered acupuncture points Maciocia35 used a combination of acupuncture points (Ki7-Ht6) and found that these points can improve some menopausal complications and decrease the rate of stop night sweating. Moreover, Linde et al.36 proved that acupuncture is an effective treatment for preventing headaches, but for a migraine, studies show similar results in groups receiving ''true'' acupuncture and groups receiving ''sham'' acupuncture.

So, more research into the mechanistic role of the activity of laser therapy to reduce the severe menopausal symptoms. In this target, the next stage of the research will be designed to increase the sample size, number of acupuncture points, the time interval of the therapy and recording more menopausal behavioral disorders to confirm or reject the laser therapy.


The present study, research concluded that laser therapy using the indicated acupuncture points improved the severity and rate of hot flashes with the improvement of the hormonal disorders.


This study discovered the valuable role of laser acupuncture in combination with drug treatment that can be beneficial for post-menopausal complications and severe consequences of hot flashes. This study will help the researchers uncover the critical areas of laser treatment, acupuncture points that many researchers were not able to explore. Thus a new theory of menopausal disorders treatment using new and way from drugs, treatments may be arrived at.


We thank all technical support teams in the department of Obstetrics and Gynecology, Suez Insurance Hospital, Suez, Egypt. Financial and material support should also be acknowledged.

1:  Soules, M.R., S. Sherman, E. Parrott, R. Rebar, N. Santoro, W. Utian and N. Woods, 2001. Executive summary: Stages of reproductive aging workshop (STRAW). Climacteric, 4: 267-272.
CrossRef  |  Direct Link  |  

2:  Avis, N.E., R.R. Coeytaux, S. Isom, K. Prevette and T. Morgan, 2016. Acupuncture in Menopause (AIM) study: A pragmatic, randomized controlled trial. Menopause, 23: 626-637.
CrossRef  |  PubMed  |  Direct Link  |  

3:  Greendale, G.A., N.P. Lee and E.R. Arriola, 1999. The menopause. Lancet, 353: 571-580.
CrossRef  |  PubMed  |  Direct Link  |  

4:  Genazzani, A.R., N. Pluchino, F. Bernardi, M. Centofanti and M. Luisi, 2006. Beneficial effect of tibolone on mood, cognition, well-being and sexuality in menopausal women. Neuropsychiatric Dis. Treat., 2: 299-307.
PubMed  |  Direct Link  |  

5:  Innes, K.E., T.K. Selfe and A. Vishnu, 2010. Mind-body therapies for menopausal symptoms: A systematic review. Maturitas, 66: 135-149.
CrossRef  |  Direct Link  |  

6:  Chiu, H.Y., C.H. Pan, Y.K. Shyu, B.C. Han and P.S. Tsai, 2015. Effects of acupuncture on menopause-related symptoms and quality of life in women in natural menopause: A meta-analysis of randomized controlled trials. Menopause, 22: 234-244.
CrossRef  |  Direct Link  |  

7:  Dalal, P.K. and M. Agarwal, 2015. Postmenopausal syndrome. Indian J. Psychiatry, 57: 222-232.
CrossRef  |  Direct Link  |  

8:  National Institutes of Health, 2005. NIH State-of-the-Science Conference statement on management of menopause-related symptoms. NIH Consens. State Sci. Statements, 22: 1-38.
PubMed  |  Direct Link  |  

9:  Kobayashi, A., M. Uefuji and W. Yasumo, 2010. History and progress of Japanese acupuncture. Evidence-Based Complement. Altern. Med., 7: 359-365.
CrossRef  |  Direct Link  |  

10:  Zhou, J., F. Qu, X. Sang, X. Wang and R. Nan, 2011. Acupuncture and auricular acupressure in relieving menopausal hot flashes of bilaterally ovariectomized Chinese women: A randomized controlled trial. Evidence-Based Complement. Altern. Med., Vol. 2011. 10.1093/ecam/nep001

11:  Freeman, E.W. and K. Sherif, 2007. Prevalence of hot flushes and night sweats around the world: A systematic review. Climacteric, 10: 197-214.
CrossRef  |  Direct Link  |  

12:  Prentice, R.L., J.E. Manson, R.D. Langer, G.L. Anderson and M. Pettinger et al., 2009. Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am. J. Epidemiol., 170: 12-23.
Direct Link  |  

13:  NAMS., 2012. The 2012 hormone therapy position statement of the North American Menopause Society. Menopause, 19: 257-271.
CrossRef  |  PubMed  |  Direct Link  |  

14:  Stearns, V., L. Ullmer, J.F. Lopez, Y. Smith, C. Isaacs and D. Hayes, 2002. Hot flushes. Lancet, 360: 1851-1861.
CrossRef  |  Direct Link  |  

15:  Gold, E.B., Y. Bair, G. Zhang, J. Utts and G.A. Greendale et al., 2007. Cross-sectional analysis of specific Complementary and Alternative Medicine (CAM) use by racial/ethnic group and menopausal status: The study of Women's Health Across the Nation (SWAN). Menopause, 14: 612-623.
CrossRef  |  Direct Link  |  

16:  Avis, N.E., S.L. Crawford, G. Greendale, J.T. Bromberger and S.A. Everson-Rose et al., 2015. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Internal Med., 175: 531-539.
CrossRef  |  Direct Link  |  

17:  Li, J., M. Eriksson, K. Czene, P. Hall and K.A. Rodriguez-Wallberg, 2016. Common diseases as determinants of menopausal age. Hum. Reprod., 31: 2856-2864.
CrossRef  |  Direct Link  |  

18:  Borud, E.K., M. Martinussen, A.E. Eggen and S. Grimsgaard, 2009. The Women's Health Questionnaire (WHQ): A psychometric evaluation of the 36‐item Norwegian version. Scand. J. Psychol., 50: 183-189.
CrossRef  |  Direct Link  |  

19:  Wathen, C.N., 2006. Alternatives to hormone replacement therapy: A multi-method study of women's experiences. Complement. Ther. Med., 14: 185-192.
CrossRef  |  Direct Link  |  

20:  Ernst, E., 2006. Acupuncture-a critical analysis. J. Internal Med., 259: 125-137.
CrossRef  |  Direct Link  |  

21:  Newton, K.M., D.S.M. Buist, N.L. Keenan, L.A. Anderson and A.Z. LaCroix, 2002. Use of alternative therapies for menopause symptoms: Results of a population-based survey. Obstet. Gynecol., 100: 18-25.
CrossRef  |  Direct Link  |  

22:  Nasir, L.S., 2002. Acupuncture. Primary Care: Clin. Office Pract., 29: 393-405.
CrossRef  |  Direct Link  |  

23:  Whittaker, P., 2004. Laser acupuncture: Past, present and future. Lasers Med. Sci., 19: 69-80.
CrossRef  |  Direct Link  |  

24:  Pearl, D. and E. Schrollinger, 1999. Acupuncture: Its use in medicine. Western J. Med., 171: 176-180.
PubMed  |  Direct Link  |  

25:  Cohen, S.M., M.E. Rousseau and B.L. Carey, 2003. Can acupuncture ease the symptoms of menopause? Holistic Nurs. Pract., 17: 295-299.
Direct Link  |  

26:  Malterud, K., 2001. Qualitative research: Standards, challenges and guidelines. Lancet, 358: 483-488.
CrossRef  |  Direct Link  |  

27:  Manson, J.E., R.T. Chlebowski, M.L. Stefanick, A.K. Aragaki and J.E. Rossouw et al., 2013. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. J. Am. Med. Assoc., 310: 1353-1368.
CrossRef  |  Direct Link  |  

28:  Zibecchi, L., G.A. Greendale and P.A. Ganz, 2003. Comprehensive menopausal assessment: An approach to managing vasomotor and urogenital symptoms in breast cancer survivors. Oncol. Nurs. Forum, 30: 393-407.
CrossRef  |  PubMed  |  Direct Link  |  

29:  Gaspar, A., G. Addamo and H. Brandi, 2011. Vaginal fractional CO2 laser: A minimally invasive option for vaginal rejuvenation. Am. J. Cosmetic Surg., 28: 156-162.
CrossRef  |  Direct Link  |  

30:  Qu, F., J. Zhou and R. Nan, 2007. Acupuncture for perimenopausal symptoms in women who underwent oophorectomy-a comparative study. Complement. Med. Res., 14: 25-32.
Direct Link  |  

31:  Pachman, D.R., D. Barton, P.E. Carns, P.J. Novotny and S. Wolf et al., 2011. Pilot evaluation of a stellate ganglion block for the treatment of hot flashes. Supportive Care Cancer, 19: 941-947.
CrossRef  |  Direct Link  |  

32:  Clayton, A.H. and P.T. Ninan, 2010. Depression or menopause? Presentation and management of major depressive disorder in perimenopausal and postmenopausal women. Primary Care Companion J. Clin. Psychiatry, Vol. 12. 10.4088/PCC.08r00747blu

33:  Bojanini, J.F. and A.M. Mejia, 2014. Laser treatment of vaginal atrophy in post-menopause and post-gynecological cancer patients. J. Laser Health Acad., 2014: 65-71.
Direct Link  |  

34:  Scheid, V., 2007. Traditional Chinese medicine-what are we investigating?: The case of menopause. Complement. Ther. Med., 15: 54-68.
CrossRef  |  Direct Link  |  

35:  Maciocia, G., 1998. Obstetrics and Gynecology in Chinese Medicine. 1st Edn., Churchill Livingstone, Edinburgh, UK., ISBN-13: 9780443054587, pp: 741-762.

36:  Linde, K., G. Allais, B. Brinkhaus, E. Manheimer, A. Vickers and A.R. White, 2009. Acupuncture for tension-type headache. Cochrane Database Syst. Rev. 10.1002/14651858.CD007587

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