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Anti-cancer Activity Exhibited by Boesenbergia species Plants: An Experimental Study

Muhammad Sarwar
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Muhammad Sarwar , 2012. Anti-cancer Activity Exhibited by Boesenbergia species Plants: An Experimental Study. Research Journal of Medicinal Plants, 6: 2-2.

DOI: 10.17311/rjmp.2012.2.2

Received: March 25, 2011; Accepted: July 01, 2011; Published: September 08, 2011

Medicinal plants are gaining popularity due to fewer side effects, better compatibility and in case of some chronic diseases as an only available source of treatment (Karim et al., 2011).

Anti-cancer activity of different Boesenbergia species has been discovered jointly by the researchers at the Institute for Tropical Biology and Conservation, Laboratory of Natural Products, Universiti Malaysia, Faculty of Civil Engineering and Environment, Universiti Tun Hussein Onn, Malaysia and Faculty of Medicine and Health Sciences, Universiti Putra, Malaysia.

According to new experimental study, Boesenbergia rotunda sub-stantiated best anticancer medicinal plant. This plant showed most significant anti proliferative activity against different cancer cell lines such as ovarian (CaOV), breast (MDA-MB-231 and MCF-7), cervical 3 (HeLa) and colon (HT-29) as compared with standard drugs.

Similarly, rhizome of Boesenbergia pulchellavarattenuata and Boesenbergia armeniaca also showed significant anti proliferative response but it was effective only against hormone dependent breast cancer MCF-7 cell lines.

Researchers found that all the plant extracts tested were less effective against control cell lines (3T3-mouse fibroblast) as compared with standard drugs which prove that these extracts are safe against normal cell lines.

Amazingly the rhizome of Boesenbergia showed better anti-proliferative response as compared with leaves of all Boesenbergia species against different cancer cell lines. A dose dependent growth inhibition at different concentration of drug was also observed by researchers.

Earlier study also showed that the compounds isolated from the rhizomes of Boesenbergia species was very much effective against HL-60 cancer cell line and the active constituents of Boesenbergia revealed most potent cytotoxic activity (Sukari et al., 2007).

In order to achieve the therapeutic benefits, further study is required to investigate the anticancer activity of these plants extract with special reference to their effect on inducing the cell apoptosis. Authors are planning to perform more definitive study using advanced research techniques in near future.


1:  Sukari, M.A., A.Y.L. Ching, G.C. Lian, M. Rahmani and K. Khalid, 2007. Cytotoxic constituents from Boesenber giapandurata (Roxb.) Schltr. Nat. Prod. Sci., 13: 110-113.
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2:  Karim, A., M.N. Sohail, S. Munir and S. Sattar, 2011. Pharmacology and phytochemistry of Pakistani herbs and herbal drugs used for treatment of diabetes. Int. J. Pharmacol., 7: 419-439.
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