Ficus carica Linn.-An Overview
Vikas V. Patil
Vijay R. Patil
Ficus carica Linn. (Moraceae) is a deciduous tree, which grows in tropical and subtropical regions of India and is commonly known as fig tree. In traditional medicine the roots are used in treatment of leucoderma and ringworms and its fruits which are sweet, have antipyretic, purgative, aphrodisiac properties and have shown to be useful in inflammations and paralysis. Ficus carica is claimed to be useful in liver and spleen disorders, to cure piles and in treatment of gout. Locally the leaves are being used in the treatment of jaundice. Charka gave the paste of figs in prescriptions, also as cooked vegetable, emaciation and debility, as a diuretic in urinary stones. Sushrusha included the fruit in a medicated clarified butter for internal use in fever, consumption, asthma, epilepsy and insanity. The present review is therefore, an effort to give a detailed survey of the literature in on its pharmacognosy, phytochemistry, traditional and pharmacological uses.
March 12, 2010; Accepted: April 29, 2010;
Published: August 13, 2010
Plants have been the major source of drugs in Indian system of medicine and
other ancient systems in the world. Earliest description of curative properties
of medicinal plants is found in Rig-Veda. Charaka Samhita and Sushrusha Samhita
give extensive description on various medicinal herbs. Information on medicinal
plants in India has been systematically organized (Kirtikar
and Basu, 1989; Ram and Malhotra, 1989; Satyavati
et al., 1976; Satyavati and Gupta, 1987).
The medicinal properties of certain plants have been known for centuries (Laughlin,
1963). More than a quarter of the medicines in use today come from plants,
i.e., from traditional medicine. Currently, with the active encouragement of
the WHO (Watt and Wood, 1988; WHO Expert
Committee Diabetes Mellitus, 1980).
Ficus carica Linn. (Mar, Hindi and Guj: Anjir ) belongs to family Moraceae.
The fig tree (Ficus carica L.) is one of the unique Ficus species
widely spread in tropical and subtropical countries which has edible fruits
with high commercial value. Commercial fig production is either located around
the Mediterranean Sea or is realized in countries possessing Mediterranean climate
as in the case of California, Australia or South America. In Turkey, the major
fig producer, around 65% of fig trees are in the Western Aegean Region especially
in Small and Big Meander valleys (Aksoy et al., 1987,
A small or moderate sized deciduous tree, 15-30 feet high with broad ovate
or nearly orbicular leaves, more or less deeply 3-5 lobed, rough above and pubescent
below; fruits axillary, usually peer shaped, variable in size and color. The
fig plant is considered to be a native of carica in Asia and is grown in nearly
all tropical and sub-tropical countries. It is now cultivated chiefly in the
Mediterranean region, from Turkey in the east to Spain and Portugal in the west;
it is also grown commercially in parts of USA and Chile and, to a small extent,
in India, Arabia china and Japan. It is grown on a wide variety of soils and
is known to do well on heavy clays, rich loams and light sandy soils with free
drainage. It thrives best in dry localities with light early rains. A dry climate
is necessary at the time of fruit development and maturation. The plant is readily
propagated by cuttings. The cuttings which should be short-joined, 8-12 in.
long and 0.5-0.7 in. diameter are taken from mature wood 2-3 years old and planted
1 feet apart each way in prepared nursery beds at the beginning of rains. The
aim of this paper is to present an overview of pharmacognostical, traditional,
phytochemical and pharmacological investigations carried out on the plant (Anonymous,
Macroscopical: A small tree with spreading branches and grayish on red
bark, leaves green, alternate palmately 3-5 lobed, hairy beneath. Inflorescence
consist of pear shaped, hollow, fleshy receptacle bearing staminate and pistillate
flowers on its inner surface. Leaves were green, odourless with slight bitter
taste. Leaves are 07-09 cm long and 04-06 cm wide, lanceolate in shape; surface
is rough on upper and pale green at lower surface, acute, apex oval, cordate
base, serrate margin and reticulate venation (Youngken, 2003).
Microscopical: The transverse section of the leaf reveals.
Lamina: Single layer of upper and lower epidermis, covered with a thin cuticle. The lower epidermis showed stomata and it was of anomocytic type. Below the upper epidermis double layer of palisade cells was found. Palisade cells are rectangular and compact. Below the palisade cell layer spongy parenchymatous cells were present in 5-6 layers. Covering, unicellular trichomes were present in large number.
Midrib: The upper and lower epidermal layers of lamina are continuous over the midrib. Two layers of collenchyma were observed above the lower epidermis. The rest of the midrib is occupied by spongy parenchyma with the vascular bundle which is of collateral type. The vascular bundle is surrounded by pericyclic fibres. The unicellular trichomes were also present.
Powder: The behavior of leaf powder upon treatment with different chemical reagents was also observed and reported in Table 1. Fluorescence studies of various powders with various reagents revealed the presence of green and orange fluorescence with Conc. sulphuric acid and sodium hydroxide respectively under UV light at 254 and 366 nm.
Physical constants: The physical constants such as total ash value (5.74%) acid insoluble ash (3.15%) water soluble ash (2.59%) and extractive values are specific identification. The soluble extractive values with solvents such as petroleum ether, chloroform, methanol and ethanol were 2.29, 3.52, 7 and 9.8%, respectively, which indicates the nature of constituents present. Quantitative microscopical study also give valuable information regarding specific leaf constants such as vein islet (20 mm-2),vein termination number (12 mm-2) stomatal number (8.5 and 18 mm-2) upper and lower epidermis, respectively (Fig. 1).
|| Behavior of powdered leaves of Ficus carica with different
|| Fruits and leaves of Ficus carica
Traditional uses: The juice of the fruit with honey was prescribed for
checking haemorrhage (Vrindamaadhava). In unani medicine, anjeer is used as
a mild laxative, expectorant, diuretic; also in the diseases of the liver and
spleen as a deobstruent and anti-inflammatory agent. Ficus carica and
Juglans regia (Akharot) from a good aphrodisiac tonic in unani medicine Anjeer
as a dry fruit is also considered a good nutritional support for diabetics (Khare,
2004). In traditional medicine the roots are used in treatment of leucoderma
and ringworms and its fruit which are sweet, have antipyretic, purgative, aphrodisiac
properties and have shown to be useful in inflammation and paralysis. Ficus
carica is claimed to be useful in liver and spleen disorders, to cure piles
and in treatment of gout. Locally the leaves are being used in the treatment
of jaundice (Kirthikar and Basu, 1996; Nadkarnim
and Nadkarni, 1995).
Phytochemical properties: Earlier chemical examination of this plant
have shown the presence of Psoralen, bergapten, umbelliferone (Kang
et al., 1995; Louis et al., 2000),
β-sitosterol, campesterol, stigmasterol, fucosterol, fatty acids (Jeong
and Lachance, 2001), 6-(2-methoxy-Z-vinyl)-7-methyl pyranocoumarin and 9,19
cycloarlane triterpenoid as an anticancer (Weiping et
al., 1997a, b) and antiproliferative agent:
6-O-acyl-β-D-glucosyl-β-sitosterol (Rubnov et
al., 2001), calotropenyl acetate and lupeol acetate (Saeed
and Sabir, 2002).
Hepatoprotective activity: The methanol extract of the leaves of Ficus
carica Linn. (Moraceae) was evaluated for hepatoprotective activity in rats
with liver damage induced by carbon tetrachloride. The extract at an oral dose
of 500 mg kg-1 exhibited a significant protective effect by lowering
the serum levels of aspartate aminotransferase, alanine aminotransferase, total
serum bilirubin and malondialdehyde equivalent, an index of lipid peroxidation
of the liver (Mohan et al., 2007). The effect
of petroleum ether and ethanol extracts of Ficus carica was evaluated
in ethanol induced hepatotoxicity in rats. Liver cirrhosis was produces by administering
repetitive dose of ethanol. The liver damage was evidenced by elevated levels
of serum bilirubin, Serum Glutamate Pyruvate Transminase (SGPT) Serum Glutamate
Transminase (SGOT) and by histopathological observations of liver sections.
Petroleum ether extract of Ficus carica leaf significantly reduces these
elevated levels of serum bilirubin, SGPT, SGOT. Ethanol induced liver cirrhosis
was also found to be reduced as observed histopathologically (Khadbadi
et al., 2007).
Shade dried leaves of Ficus carica were extracted using petroleum ether
(60-80°) and tested for antihepatotoxic activity on rats treated with 50
mg kg-1 of rifampicin orally. The parameters assessed were serum
levels of glutamic oxaloacetate transaminase, glutamic pyruvic transaminase,
bilirubin and histological changes in liver. Liver weights and pentobarbitione
sleeping time as a functional parameter were also monitored. There was significant
reversal of biochemical, histological and functional changes induced by rifampicin
treatment in rats by petroleum ether extract treatment, indicating promising
hepatoprotective activity (Gond and Khadabadi, 2008).
Hypoglycemic: The effect of a decoction of fig leaves (Ficus carica),
as a supplement to breakfast, on diabetes control was studied in insulin-dependent
diabetes mellitus (IDDM) patients (six men, four women, age 22-38 years, Body
Mass Index (BMI): 20.893.0 kg m-2, HbA1c 7.690.9% with a mean duration
of diabetes of 996.3 years). The patients were managed with their usual diabetes
diet and their twice-daily insulin injection. During the first month, patients
were given a decoction of fig leaves (FC) and during the next month a non-sweet
commercial tea (TC). The patients were divided into two groups (n_5) with random
allocation and cross-over design (Serraclara et al.,1998).
A model of hypertriglyceridaemia in rats is described, which was used to investigate the hypolipidaemic effect of an intraperitoneal (i./p.) administration of a Ficus carica leaf decoction. Hypertriglyceridaemia was induced in rats following the protocol: a fasting period of 22, 2 h of oral (p.o.) administration of 20% emulsion of longchain triglycerides (LCT emulsion), both repeated once. The plasma triglyceride and total cholesterol levels obtained 2 h after the protocol were 5.7±2.5 mmol L-1 (p<0.0001 vs basal levels) and 1.7±0.3 mmol L-1, respectively, n = 10. The new model was used to test the hypotriglyceridaemic effect of a single dose of Ficus carica (fig tree) leaf decoction administered i./p. (50 g dry wt kg-1 b.wt.). After the i.p. injection of serum saline (control group, n = 10) or Ficus carica extract (group A, n = 10), plasma triglyceride levels in the control group and group A were 5.9±2.9 and 5.5±2.9 mmol L-1 just after the LCT emulsion protocol; 4.7±2.7 and 0.9±0.4 mmol L-1, p<0.005, 60 min after the LCT protocol and 3.6±2.9 mmol L-1 and 1.0±0.4 mmol L-1, p<0.05, 90 min after the LCT protocol. The plasma total cholesterol levels, which were not modified in our experimental model, showed no significant differences in relation to baseline levels in the presence or absence of Ficus carica treatment either.
The clearly positive results suggest the presence in the fig leaf decoction
of a compound or compounds that influence lipid catabolism (Perez
et al., 1999).
Oxidative stress: Parameters related to oxidative stress were studied
in rats divided into 4 groups: streptozotocin-induced diabetic rats (n = 10),
diabetic rats who received a single dose of a basic fraction of Ficus carica
extract (n = 14), diabetic rats who received a single dose of a chloroform
fraction of the extract (n = 10) and normal rats (n = 10). Compared to normal
animals, the diabetic animals presented significantly higher values for erythrocyte
catalase normalized to haemoglobin levels (1.5±0.15 vs. 0.96±0.18
μg mg-1) and for plasma vitamin E (73.4±43.9 vs. 12.0±1.6
mg L-1), monounsaturated fatty acids (0.219±0.118 vs. 0.067±0.014
mg mL-1), polyunsaturated fatty acids (PUFA, 0.567±0.293 vs.
0.175±0.040 mg mL-1), saturated fatty acids (0.779±0.262
vs. 0.401±0.055 mg mL-1) and linoleic acid (0.202±0.086
vs. 0.106±0.014 mg mL-1). Both Ficus carica fractions
tended to normalize the values of the diabetic animals fatty acids and
plasma vitamin E values. On studying the ratios of vitamins E and A to PUFA
(129.4±77.5 diabetic and 68.8±9.1 μg mg-1 normal;
37.5±20.8 vs. 108.0±43.6 μg mg-1) and to C18:2
(259.9±65.8 vs. 161.0±21.3 μg mg-1; 68.3±37.9
vs. 252.7±102.1 μg mg-1), we found statistically significant
differences as a function of diabetes, with the vitamin E/C18:2 ratio being
normalized by the administration of the chloroform fraction (to 152.1±80.3
μg mg-1) and the vitamin A/C18:2 ratio being raised relative
to the untreated diabetic rats by the administration of the basic fraction (91.9±14.5
μg mg-1). Present work confirms that antioxidant status is affected
in the diabetes syndrome and that Ficus carica extracts tend to normalize
it ( Perez et al., 2003).
Antifungal: A low-molecular-weight protein with antifungal activity
was isolated from freshly collected latex of the Inzhir tree (Ficus carica
L.) by successive affinity chromatography over chitin, cation-exchange chromatography
over SP-Sephadex C-50 and reversed-phase HPLC. The molecular weight of 6481
and the partial N-terminus sequence of the protein were determined (Mavlonov
et al., 2008).
Antispasmodic: To rationalize the medicinal use of gig (Ficus carica) in gastrointestinal and inflammatory disorders. The aqueous-ethanolic extract of Ficus carica (Fc.Cr) was studied for antispasmodic effect on the isolated rabbit jejunum preparations and for antiplatelet effect using ex vivo model of human platelets.
Fc.Cr tested positive for alkaloids, flavonoids, coumarins, saponins, sterols
and terpenes. When tested in isolated rabbit jejunum, Fc.Cr (0.1-3.0 mg mL-1)
produced relaxation of spontaneous and low K+ (25 mM)-induced contractions
with negligible effect on high K+ (80 mM) similar to that caused
by cromakalim. Pretreatment of the tissue with glibenclamide caused rightward
shift in the curves of low K+-induced contractions. Similarly, cromakalim
inhibited the contractions induced by low K+, but not of high K+,
while verapamil equally inhibited the contractions of K+ at both
concentrations. Fc.Cr (0.6 and 0.12 mg mL-1) inhibited the adenosine
5_-diphosphate and adrenaline-induced human platelet aggregation. This study
showed the presence of spasmolytic activity in the ripe dried fruit of Ficus
carica possiblymediated through the activation of K+ ATP channels
along with antiplatelet activity which provides sound pharmacological basis
for its medicinal use in the gut motility and inflammatory disorders (Gilani
et al., 2008).
Antipyretic: A study was carried out to evaluate the antipyretic effect
of an ethanol extract of leaves, of Ficus carica Linn. belonging to the
family of Moraceae, at normal body temperature and yeast-induced pyrexia, in
albino rats. A yeast suspension (10 mL kg-1 b.wt.) increased rectal
temperature 19 h after the subcutaneous injection. The ethanol extract of Ficus
carica, at doses of 100, 200 and 300 mg kg-1 b.wt. p.o., showed
significant dose-dependent reduction in normal body temperature and yeast-provoked
elevated temperature. The effect extended up to five hours after drug administration.
The anti-pyretic effect of the ethanol extract of Ficus carica was comparable
to that of Paracetamol (150 mg kg-1 b.wt., p.o.), a standard anti-pyretic
agent (Vikas et al., 2010).
Anthelmintic: The latex of some species of Ficus (Moraceae) has
been traditionally used as vermifuge in Central and South America. It has been
accepted that anthelmintic activity is due to a proteolytic fraction called
ficin. In the present study, the anthelmintic activity of the latex of Ficus
insipida Willd. and Ficus carica L. has been investigated in NIH
mice naturally infected with Syphacia obvelata, Aspiculuris tetraptera
and Vampirolepis nana. The latex of F. insipida, administered
by intragastric route in doses of 4 mL/kg/day during three consecutive days,
were effective in the removal of 38.6% of the total number of S. obvelata,
being inexpressive in the removal of A. tetraptera (8.4%) and
segments of V. nana (6.3%). The latex of F. carica,
administered in doses of 3 mL/kg/day, during three consecutive days, was effective
in the removal of S. obvelata (41.7%) and it did not produce significant
elimination of A. tetraptera (2.6%) and V. nana (8.3%).
The observed high acute toxicity with hemorrhagic enteritis, in addition to
a weak anthelmintic efficacy, do not recommend the use of these lattices in
traditional medicine (Amorin et al., 1999).
Antioxidant: Fig. fruit has been a typical component in the health-promoting
Mediterranean diet for millennia. To study the potential health-promoting constituents
of fig fruits, six commercial fig varieties differing in color (black, red,
yellow and green) were analyzed for total polyphenols, total flavonoids, antioxidant
capacity and amount and profile of anthocyanins. Using reversed-phase liquid
chromatography (RP-LC), various concentrations of anthocyanins but a similar
profile was found in all varieties studied. Hydrolysis revealed cyanidin as
the major aglycon. Proton and carbon NMR confirmed cyanidin-3-O-rhamnoglucoside
(cyanidin-3-O-rutinoside; C3R) as the main anthocyanin in all fruits. Color
appearance of fig extract correlated well with total polyphenols, flavonoids,
anthocyanins and antioxidant capacity. Extracts of darker varieties showed higher
contents of phytochemicals compared to lighter colored varieties. Fruit skins
contributed most of the above phytochemicals and antioxidant activity compared
to the fruit pulp. Antioxidant capacity correlated well with the amounts of
polyphenols and anthocyanins (R2 = 0.985 and 0.992, respectively).
In the dark-colored Mission and the red Brown-Turkey varieties, the anthocyanin
fraction contributed 36 and 28% of the total antioxidant capacity, respectively.
C3R contributed 92% of the total antioxidant capacity of the anthocyanin fraction.
Fruits of the Mission variety contained the highest levels of polyphenols, flavonoids
and anthocyanins and exhibited the highest antioxidant capacity (Solomon
et al., 2006).
Antimutagenic: Antimutagenic action of plant extracts of Armoracia
rusticana, Ficus carica, Zea mays and their mixture on environmental
xenobiotics has been investigated. The plant extracts and their mixture decreased
the level of mutations induced by N-metil-N'-nitro-N-nitrozoguanidin (MNNG)
in Vicia faba cells, chlorophyll mutations in Arabidopsis thaliana and NaF induced
mutability in rat marrow cells. The studied plant extracts and their mixture
demonstrate the ability to decrease the genotoxicity of environmental mutagens
(Agabeili and Kasimova, 2005).
Anti-HSV: To study the anti-HSV effect of the extract from the leaves
of Ficus carica. The effective ingredient was extracted from the leaves
of Ficus carica and the anti-virus effect was observed on Hep-2, BHK21
and PRK cells. The water extract from the leaves of Ficus carica possessed
distinct anti-HSV-1 effect. The MTC was 0.5 mg mL-1, TDO was 15 mg
mL-1 and TI was 30.0. It possessed low toxicity and directly killing-virus
effect on HSV-1. The leaves of Ficus carica possess anti-HSV-1 effect
and their application on the area of medicine, food and drugs has expansive
foreground (Wang et al., 2004).
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