Debayo M. Bolarin
Department of Chemical Pathology and Immunology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
Ekpe Lawson Ekpe
Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
Kasimu Saidu
Department of Chemical Pathology and Immunology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
Eyam Sunday Eyam
Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
ABSTRACT
The biomarkers of bone metabolism are proteins, which are synthesized by the osteoblast and osteoclast and are released into the bloodstream or circulation as fragments during the formation or degradation of type I collagen. Because some of these fragments are small, they are filtered by the kidney into urine, but the larger fragments which are not filtered are detected in the blood samples. Disorders or disease conditions of skeletal metabolism result in the release of these fragments, which are products of osteoblastic and/or osteoclastic activity. Measurements of these biomarkers of bone metabolism by immunoassay methods show promise as important adjuncts in the early diagnosis of bone changes. These biomarkers are also important in the evaluation and management of skeletal complications of sickle cell disease and other disorders of bone; however they are affected by a variety of physiological and pathological factors. In conclusion, biochemical bone biomarkers are convenient, non-invasive indices of bone metabolic activities, but other analytes such as parathyroid hormone and 25-hydroxycholecalciferol or calcidiol may also be considered.
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How to cite this article
Debayo M. Bolarin, Ekpe Lawson Ekpe, Kasimu Saidu and Eyam Sunday Eyam, 2016. A Glance at Biomarkers of Bone Metabolism. Pakistan Journal of Nutrition, 15: 499-504.
DOI: 10.3923/pjn.2016.499.504
URL: https://scialert.net/abstract/?doi=pjn.2016.499.504
DOI: 10.3923/pjn.2016.499.504
URL: https://scialert.net/abstract/?doi=pjn.2016.499.504
REFERENCES
- Akesson, K., 1995. Biochemical markers of bone turnover: A review. Acta Orthopaedica Scandinavica, 66: 376-386.
CrossRefDirect Link - Bolarin, D.M., 2006. Review of biochemical bone markers in sickle cell disease. Nigerian J. Orthopaedics Trauma, 4: 1-15.
CrossRefDirect Link - Bolarin, M., 1986. Serum enzymes of collagen synthesis and type III procollagen amino-propeptide in Nigerian patients with sickle cell disease. Clin. Chem. Lab. Med., 24: 433-436.
Direct Link - Bolarin, D.M., P. Swerdlow, A.M. Wallace and L. Littsey, 1998. Type I collagen as a marker of bone metabolism in sickle cell hemoglobinopathies. J. Nat. Med. Assoc., 90: 41-45.
Direct Link - Bolarin, D.M., 2001. Bone-specific alkaline phosphatase protein, total alkaline phosphatase activity and lactate dehydrogenase in sera of patients with sickle cell disease. Haematologia, 31: 51-56.
CrossRefDirect Link - Bolarin, D. and E. Azinge, 2010. Osteocalcin and specific markers of bone resorption in sickle cell disease. Acta Physiol. Hungarica, 97: 290-296.
CrossRefDirect Link - Bonnick, S.L. and L. Shulman, 2006. Monitoring osteoporosis therapy: Bone mineral density, bone turnover markers, or both? Am. J. Med., 119: S25-S31.
Direct Link - Compston, J., 2009. Monitoring bone mineral density during antiresorptive treatment for osteoporosis. BMJ, Vol. 338.
CrossRef - Coleman, R., L. Costa, F. Saad, R. Cook and P. Hadji et al., 2011. Consensus on the utility of bone markers in the malignant bone disease setting. Critic. Rev. Oncol./Hematol., 80: 411-432.
Direct Link - De la Piedra, C., A. Rapado, E.D. Diego, M.D. Martin, C. Aguirre, E.L. Gavilanes and M.D. Curiel, 1996. Variable efficacy of bone remodeling biochemical markers in the management of patients with Paget's disease of bone treated with tiludronate. Calcified Tissue Int., 59: 95-99.
CrossRefDirect Link - Fontana, A. and P.D. Delmas, 2000. Markers of bone turnover in bone metastases. Cancer, 88: 2952-2960.
CrossRefDirect Link - Ferron, M., E. Hinoi, G. Karsenty and P. Ducy, 2008. Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Nat. Acad. Sci., 105: 5266-5270.
CrossRefDirect Link - Garnero, P., E. Sornay-Rendu, B. Claustrat and P.D. Delmas, 2000. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study. J. Bone Mineral Res., 15: 1526-1536.
CrossRefDirect Link - Garnero, P., M. Grimaux, P. Seguin and P.D. Delmas, 1994. Characterization of immunoreactive forms of human osteocalcin generated in vivo and in vitro. J. Bone Mineral Res., 9: 255-264.
CrossRefDirect Link - Hwang, Y.C., I.K. Jeong, K.J. Ahn and H.Y. Chung, 2009. The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects. Diabetes/Metab. Res. Rev., 25: 768-772.
CrossRefDirect Link - Lipton, A., L. Costa and R.E. Coleman, 2011. Bone turnover markers: Tools for prognosis and monitoring response to bisphosphonates? Breast Dis., 33: 59-69.
CrossRefDirect Link - Sorva, R., R. Tahtela, M. Turpeinen, K. Juntunen‐Backman and T. Haahtela et al., 1996. Changes in bone markers in children with asthma during inhaled budesonide and nedocromil treatments. Acta Paediatrica, 85: 1176-1180.
CrossRefDirect Link - Vasikaran, S., R. Eastell, O. Bruyere, A.J. Foldes and P. Garnero et al., 2011. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards. Osteoporosis Int., 22: 391-420.
CrossRefDirect Link