Subscribe Now Subscribe Today
Research Article
 

Hyperuricemia and its Association with the Presence of Metabolic Syndrome among Indonesian Obese Adolescents



Adriyan Pramono, Nuryanto , Etisa Adi Murbawani, Binar Panunggal and Gemala Anjani
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

Metabolic syndrome (MetS) plays an important role in inflammation and insulin resistance. Increasing number of adolescents MetS were common among obese. The inflammatory biomarkers may contribute to increasing levels of uric acid (UA). Currently UA is not only associated with gout, but also cardiovascular disease. This was a cross sectional study conducted in Semarang City, Indonesia. Consecutive sampling for obese adolescents was administrated. About 81 obese adolescents from two government highs schools were recruited in this study. We measured anthropometry (weight, height, waist circumference, neck circumference), clinical data (systolic and diastolic blood pressure) and biochemical data (triglyceride, HDL-cholesterol, fasting blood glucose, uric acid). A subjects was categorized as MetS if presence 3 or more components of MetS. Gender and Hyperuricemia was associated with presence of MetS (p = 0.048 and p = 0.004). The mean levels of UA increased accordance to the amount of MetS components (p = 0.000). Regression logistic analysis concluded that hyperuricemia as major risk factor of MetS among obese adolescents (OR = 3.97). Hyperuricemia contributed to metabolic syndrome among Indonesian obese adolescents.

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Adriyan Pramono, Nuryanto , Etisa Adi Murbawani, Binar Panunggal and Gemala Anjani, 2016. Hyperuricemia and its Association with the Presence of Metabolic Syndrome among Indonesian Obese Adolescents. Pakistan Journal of Nutrition, 15: 238-243.

DOI: 10.3923/pjn.2016.238.243

URL: https://scialert.net/abstract/?doi=pjn.2016.238.243

REFERENCES
1:  Aswathappa, J., S. Garg, K. Kutty and V. Shankar, 2013. Neck circumference as an anthropometric measure of obesity in diabetics. North Am. J. Med. Sci., 5: 28-31.
CrossRef  |  Direct Link  |  

2:  Baldwin, W., S. McRae, G. Marek, D. Wymer and V. Pannu et al., 2011. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes, 60: 1258-1269.
CrossRef  |  Direct Link  |  

3:  Cardoso, A.S., N.C. Gonzaga, C.C.M. Medeiros and D.F. de Carvalho, 2013. Association of uric acid levels with components of metabolic syndrome and non-alcoholic fatty liver disease in overweight or obese children and adolescents. Jornal Pediatria (Versao Portugues), 89: 412-418.
CrossRef  |  Direct Link  |  

4:  Evia-Viscarra, M.L., E.R. Rodea-Montero, E. Apolinar-Jimenez and S. Quintana-Vargas, 2013. Metabolic syndrome and its components among obese (BMI ≥95th) Mexican adolescents. Endocrine Connections, 2: 208-215.
CrossRef  |  Direct Link  |  

5:  Feig, D.I., D.H. Kang and R.J. Johnson, 2008. Uric acid and cardiovascular risk. New Eng. J. Med., 359: 1811-1821.
CrossRef  |  Direct Link  |  

6:  Ferretti, R.L., I.P. Cintra, M.A. Passos, G.L. Ferrari and M. Fisberg, 2015. Elevated neck circumference and associated factors in adolescents. BMC Public Health, Vol. 15. 10.1186/s12889-015-1517-8

7:  Grundy, S.M., H.B. Brewer Jr., J.I. Cleeman, S.C. Smith Jr. and C. Lenfant, 2004. Definition of metabolic syndrome: Report of the National Heart, Lung and Blood Institute/American Heart Association Conference on scientific issues related to definition. Circulation, 109: 433-438.
CrossRef  |  Direct Link  |  

8:  Ministry of Health, 2013. [Basic health research in year 2013]. Report, Ministry of Health, Indonesia. http://www.litbang.depkes.go.id/sites/download/rkd2013/Laporan_Riskesdas2013.PDF, (In Indonesian).

9:  Kanellis, J. and D.H. Kang, 2005. Uric acid as a mediator of endothelial dysfunction, inflammation and vascular disease. Semin. Nephrol., 25: 39-42.
CrossRef  |  Direct Link  |  

10:  Klein, S., D.B. Allison, S.B. Heymsfield, D.E. Kelley, R.L. Leibel, C. Nonas and R. Kahn, 2007. Waist circumference and cardiometabolic risk: A consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition and the American Diabetes Association. Diabetes Care, 30: 1647-1652.
CrossRef  |  Direct Link  |  

11:  Kanda, H., S. Tateya, Y. Tamori, K. Kotani and K.I. Hiasa et al., 2006. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance and hepatic steatosis in obesity. J. Clin. Invest., 116: 1494-1505.
CrossRef  |  Direct Link  |  

12:  Lloyd, L.J., S.C. Langley-Evans and S. McMullen, 2012. Childhood obesity and risk of the adult metabolic syndrome: A systematic review. Int. J. Obesity, 36: 1-11.
CrossRef  |  Direct Link  |  

13:  Lippi, G., M. Montagnana, M. Franchini, E.J. Favaloro and G. Targher, 2008. The paradoxical relationship between serum uric acid and cardiovascular disease. Clinica Chimica Acta, 392: 1-7.
CrossRef  |  PubMed  |  Direct Link  |  

14:  Li, C., M.C. Hsieh and S.J. Chang, 2013. Metabolic syndrome, diabetes and hyperuricemia. Curr. Opin. Rheumatol., 25: 210-216.
CrossRef  |  PubMed  |  Direct Link  |  

15:  Lv, Q., X.F. Meng, F.F. He, S. Chen and H. Su et al., 2013. High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies. PloS One, Vol. 8. 10.1371/journal.pone.0056864

16:  McGill, Jr. H.C., C.A. McMahan, E.E. Herderick, G.T. Malcom, R.E. Tracy and J.P. Strong, 2000. Origin of atherosclerosis in childhood and adolescence. Am. J. Clin. Nutr., 72: 1307s-1315s.
Direct Link  |  

17:  Manzato, E., 2007. Uric acid: An old actor for a new role. Internal Emerg. Med., 2: 1-2.
CrossRef  |  Direct Link  |  

18:  Nagahama, K., K. Iseki, T. Inoue, T. Touma, Y. Ikemiya and S. Takishita, 2004. Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertens. Res., 27: 227-233.
CrossRef  |  Direct Link  |  

19:  Nakagawa, T., D.H. Kang, D. Feig, L.G. Sanchez-Lozada and T.R. Srinivas et al., 2006. Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease. Kidney Int., 69: 1722-1725.
CrossRef  |  Direct Link  |  

20:  Pacifico, L., V. Cantisani, C. Anania, E. Bonaiuto, F. Martino, R. Pascone and C. Chiesa, 2009. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children. Eur. J. Endocrinol., 160: 45-52.
CrossRef  |  Direct Link  |  

21:  Rashidi, H., S.P. Payami, S.M. Latifi, M. Karandish and A.M. Aleali et al., 2014. Prevalence of metabolic syndrome and its correlated factors among children and adolescents of Ahvaz aged 10-19. J. Diabetes Metab Disord, Vol. 13.

22:  Sewaybricker, L.E., M.A.R.G.M. Antonio, R.T. Mendes, A.D.A. Barros Filho and M.P. Zambon, 2013. Metabolic syndrome in obese adolescents: What is enough? Revista Associacao Medica Brasileira, 59: 64-71.
CrossRef  |  Direct Link  |  

23:  Thaman, R.G. and G.P. Arora, 2013. Metabolic syndrome: Definition and pathophysiology-the discussion goes on! J. Physiol. Pharmacol. Adv., 3: 48-56.
CrossRef  |  Direct Link  |  

24:  NCEP., 2002. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III) final report. Circulation, 106: 3143-3421.
CrossRef  |  PubMed  |  Direct Link  |  

25:  Tang, L., M. Kubota, A. Nagai, K. Mamemoto and M. Tokuda, 2010. Hyperuricemia in obese children and adolescents: The relationship with metabolic syndrome. Pediatr. Rep., Vol. 2. 10.4081/pr.2010.e12

26:  WHO., 2007. WHO child growth standards: Head circumference-for-age, arm circumference-for-age, triceps skinfold-for-age and subscapular skinfold-for-age: Methods and development. World Health Organization, Geneva, Switzerland.

27:  Xu, J., H. Peng, Q. Ma, X. Zhou and W. Xu et al., 2014. Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: A community-based cross-sectional study. Lipids Health Dis., Vol. 13.

28:  Zimmet, P., K.G.M.M. Alberti, F. Kaufman, N. Tajima and M. Silink et al., 2007. The metabolic syndrome in children and adolescents-an IDF consensus report. Pediatr. Diabetes, 8: 299-306.
CrossRef  |  PubMed  |  Direct Link  |  

29:  Zhang, M.L., Y.X. Gao, X. Wang, H. Chang and G.W. Huang, 2013. Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults. J. Clin. Biochem. Nutr., 52: 38-42.
CrossRef  |  Direct Link  |  

30:  Zhu, Y., Y. Hu, T. Huang, Y. Zhang and Z. Li et al., 2014. High uric acid directly inhibits insulin signalling and induces insulin resistance. Biochem. Biophys. Res. Commun., 447: 707-714.
CrossRef  |  Direct Link  |  

©  2020 Science Alert. All Rights Reserved