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Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats



Aida Zarfeshani, Mohd Sokhini Abd Mutalib and Huzwah Khaza`ai
 
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ABSTRACT

It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fructose diet-induced rats. The HFD was induced through drinking water in 21% (w/v) concentration among male Sprague-Dawley rats. The high fructose diet administration was unable to induce hyperglycemia, hypertriglyceridemia or any classic inflammatory markers. Also, no histological inflammation was observed. It was concluded that healthy Sprague-Dawley rats fed high fructose diet for 2.5 months could not develop signs of diabetes mellitus type 2.

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  How to cite this article:

Aida Zarfeshani, Mohd Sokhini Abd Mutalib and Huzwah Khaza`ai, 2012. Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats. Pakistan Journal of Nutrition, 11: 21-26.

DOI: 10.3923/pjn.2012.21.26

URL: https://scialert.net/abstract/?doi=pjn.2012.21.26

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