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Research Article
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Effect of Acalypha wilkesiana on Activities of Some Liver Function Enzymes and Body Weight of Normal Rabbits
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Omage Kingsley,
Erifeta O. Georgina,
Josiah J. Sunday,
Uhunmwangho S. Esosa,
Nwangwu C. Spencer,
Njoya K. Helen
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Asuk A. Agbor
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ABSTRACT
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The effects of Acalypha wilkesiana leaves on serum ALT and AST activities and body weight of normal rabbits were investigated. Oral administration of the leaf, in the form of decoction prepared by mixing 5 g of air-dried powdered leaves in 10 ml distilled water, at a dose of 1 g/kg body weight for a period of 8 and 15 days, caused a significant increase (p<0.05) in the activities of serum ALT and a significant decrease (p<0.05) in AST activities in normal rabbits. The treatment also led to a significant reduction (p<0.05) on the body weight of the experimental animals. This effect of the plant is a reflection of the relative safety of the plant in the management of hypertension and its possible use as a weight reduction therapy.
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How
to cite this article:
Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday, Uhunmwangho S. Esosa, Nwangwu C. Spencer, Njoya K. Helen and Asuk A. Agbor, 2011. Effect of Acalypha wilkesiana on Activities of Some Liver Function Enzymes and Body Weight of Normal Rabbits. Pakistan Journal of Nutrition, 10: 552-554.
DOI: 10.3923/pjn.2011.552.554
URL: https://scialert.net/abstract/?doi=pjn.2011.552.554
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REFERENCES |
1: Adesina, S.K., O. Idowu, A.O. Ogundaini, H. Oladimeji, T.A. Olugbade, G.O. Onawunmi and M. Pais, 2000. Antimicrobial constituents of the leaves of Acalypha wilkesiana and Acalypha hispida. Phytother. Res., 14: 371-374.
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2: Akinde, B.E., 1986. Phytochemical and Microbiological Evaluation of the Oils from the Leaves of Acalypha wilkesiana. In: The State of Medicinal Plant Research in Nigeria, Sofowora A. (Ed.). University of Ibadan Press, Nigeria, pp: 362-363.
3: Kumar, P. and M. Clark, 2001. Liver, Biliary Tract and Pancreatic Diseases: Investigation. In: Clinical Medicine, Kumar, P. and M. Clark (Eds.). 4th Edn., W.B. Saunders Publishers Limited, USA., pp: 292-293.
4: Kuntze, O., 1981. Botanist II. Type specimens of plants from his plantae orientall-rossicae. Brittonia, 33: 246-249.
5: Ogundaini, A.O., 2005. From Greens into Medicine: Taking a Lead from Nature. Inaugural Lecture Series 176 Obafemi Awolowo University press limited, lle-lfe, Nigeria, pp: 2.
6: Oladunmoye, M.K., 2006. Comparative evaluation of antimicrobial activities and phytochemical screening of two varieties of Acalypha wilkesiana. Trends Applied Sci. Res., 1: 538-541.
CrossRef | Direct Link |
7: Giboney, P.T., 2005. Mildly elevated liver transaminase levels in the asymptomatic patient. Am. Family Physician, 71: 1105-1110.
PubMed | Direct Link |
8: Sofowora, E.A., 1984. Medicinal Plants and Traditional Medicine in Africa. John Wiley and Sons, New York, pp: 142-147.
9: Zhang, X., 1999. WHO Monographs on Selected Medicinal Plants. Vol. 1. WHO Graphics, USA., pp: 295.
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