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Research Article
 

A Multi-faceted, Fat-defending Peptide Hormone: Ghrelin



Betul Cicek and Neriman Inanc
 
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ABSTRACT

Ghrelin is a novel gastric hormone recognized in 1999 as a mediator of growth hormone release. Ghrelin is a peptide hormone in which the third amino acid usually serine is modified by an acyl acid. This modification is essential for ghrelin’s activity. Ghrelin may thus be an essential hormone for maintaining growth hormone release and energy homeostasis. Ghrelin has profound orexigenic, adipogenic and somatotrophic properties, increasing food intake and body weight. Secreted predominantly from the stomach, ghrelin is the natural ligand for the growth hormone secretagogue receptor in the pituitary gland, thus fulfilling the criteria of a brain-gut peptide. Ghrelin is an important component of an integrated regulatory system of growth and metabolism acting via the vagus nerve and is implicated in a variety of altered energy states as obesity, eating disorders, neoplasia and cachexia. It also enhances immune responses and potentially down-regulates anti-inflammatory molecules. The discovery of ghrelin has increased the current knowledge on feeding regulation, nutritional homeostasis and metabolic processes.

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  How to cite this article:

Betul Cicek and Neriman Inanc, 2011. A Multi-faceted, Fat-defending Peptide Hormone: Ghrelin. Pakistan Journal of Nutrition, 10: 393-398.

DOI: 10.3923/pjn.2011.393.398

URL: https://scialert.net/abstract/?doi=pjn.2011.393.398

REFERENCES

1:  Broglio, F., F. Prodam, E. Me, F. Riganti and B. Lucatello et al., 2005. Ghrelin: Endocrine, metabolic and cardiovascular actions. J. Endocrinol. Invest., 28: 23-25.
PubMed  |  Direct Link  |  

2:  Cummings, D.E., 2006. Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol. Behav., 89: 71-84.
CrossRef  |  

3:  De Graaf, C., W.A. Blom, P.A. Smeets, A. Stafleu and H.F. Hendriks, 2004. Biomarkers of satiation and satiety. Am. J. Clin. Nutr., 79: 946-961.
PubMed  |  Direct Link  |  

4:  De Vriese, C. and C. Delporte, 2007. Influence of ghrelin on food intake and energy homeostasis. Curr. Opin. Clin. Nutr. Metab. Care, 10: 615-619.
PubMed  |  Direct Link  |  

5:  De Vriese, C. and C. Delporte, 2008. Ghrelin: A new peptide regulating growth hormone release and food intake. Int. J. Biochem. Cell Biol., 40: 1420-1424.
CrossRef  |  

6:  Foster-Schubert, K.E., A. McTieman, R.S. Frayo, R.S. Schwarts and K.B. Rajan et al., 2005. Human plasma ghrelin levels increase during a one-year exercise program. J. Clin. Endocrinol. Metab., 90: 820-825.
PubMed  |  Direct Link  |  

7:  Fukushima, N., R. Hanada, H. Teranishi, Y. Fukue and T. Tachibana et al., 2005. Ghrelin directly regulates bone formation. J. Bone Miner. Res., 20: 790-798.
CrossRef  |  Direct Link  |  

8:  Gil-Campos, M., C.M. Aguilera, R. Canete and A. Gil, 2006. Ghrelin: A hormone regulating food intake and energy homeostasis. Br. J. Nutr., 96: 201-226.
PubMed  |  Direct Link  |  

9:  Hosoda, H., M. Kojima and K. Kangawa, 2006. Biological, physiological and pharmacological aspects of ghrelin. J. Pharmacol. Sci., 100: 398-410.
Direct Link  |  

10:  Klok, M.D., S. Jakobsdottir and M.L. Drent, 2007. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review. Obes. Rev., 8: 21-34.
CrossRef  |  PubMed  |  Direct Link  |  

11:  Kojima, M., H. Hosoda and K. Kangawa, 2004. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach. Clin. Endocrinol. Metab., 18: 517-530.
CrossRef  |  Direct Link  |  

12:  Korbonits, M., A.P. Goldstone, M. Gueorguiev and A.B. Grossman, 2004. Ghrelin-a hormone with multiple functions. Front Neuroendocrinol., 25: 27-68.
CrossRef  |  

13:  Leidy, H.J., J.K. Gardner, B.R. Frye, M.L. Snook, M.K. Schuchert, E.L. Richard and N.I. Williams, 2004. Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J. Clin. Endocrinol. Metab., 89: 2659-2664.
PubMed  |  Direct Link  |  

14:  Olszewski, P.K., H.B. Schioth and A.S. Levine, 2008. Ghrelin in the CNS: From hunger to a rewarding and memorable meal. Brain Res. Rev., 58: 160-170.
CrossRef  |  

15:  Otto, B., J. Spranger, S.C. Benoit, D.J. Clegg and M.H. Tschop, 2005. The many faces of ghrelin: New perspectives for nutrition research. Br. J. Nutr., 93: 765-771.
PubMed  |  Direct Link  |  

16:  Savino, F. and S.A. Ligouri, 2008. Update on breast milk hormones: Leptin, ghrelin and adiponectin. Clin. Nutr., 27: 42-47.
CrossRef  |  Direct Link  |  

17:  Shrestha, Y.B., K. Wickwire and S. Giraudo, 2009. Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance. Peptides, 30: 1336-1341.
CrossRef  |  

18:  Williams, D.L. and D.E. Cummings, 2005. Regulation of ghrelin in physiologic and pathophysiologic states. J. Nutr., 135: 1320-1325.
PubMed  |  Direct Link  |  

19:  Wu, J.T. and J.G. Kral, 2004. Ghrelin, integrative neuroendocrine peptide in health and disease. Ann. Surg., 239: 464-474.
PubMed  |  Direct Link  |  

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