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Research Article

Study of the Bioavailability and Clinical Studies of Calcium-Magnesium Tablets

Abdul-Wahab R. Hamad and Hamad H. Al-Jamaien
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The bioavailability of the trace elements selenium, manganese, zinc, iron etc. has been investigated using human and experimental animals as the test observations. Twenty volunteers were used for this study. All volunteers have a deficient in calcium and magnesium. All patients were administered orally a tablet of combined calcium carbonate 292.5 mg and magnesium carbonate 232.3 mg produced by Commercial Company, Jordan. The mean concentration of blood calcium and magnesium after one week of tablet supplement was 100.8±8.3 and 15.7±1.0, respectively. The results showed that calcium-magnesium tablet is the most important elements to recover patient’s deficiency. It is thus concluded that combined calcium-magnesium carbonate are the best form for those elements for people deficiency.

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  How to cite this article:

Abdul-Wahab R. Hamad and Hamad H. Al-Jamaien, 2010. Study of the Bioavailability and Clinical Studies of Calcium-Magnesium Tablets. Pakistan Journal of Nutrition, 9: 1162-1165.

DOI: 10.3923/pjn.2010.1162.1165


1:  Birge, S.J., W.A. Peck, M. Berman and G.D. Whedon, 1969. Study of calcium absorption in man: A kinetic analysis and physiologic model. J. Clin. Invest., 48: 1705-1713.
CrossRef  |  PubMed  |  Direct Link  |  

2:  Deborah, A.S. and C. Ranch, 2007. Calcium supplementation in clinical practice: A review of forms, doses and indications. Nutr. Clin. Practice, 22: 286-296.
CrossRef  |  Direct Link  |  

3:  Hanzlik, R.P., S.C. Fowler and D.H. Fisher, 2005. Relative bioavailability of calcium from calcium formate, calcium citrate and calcium carbonate. J. Pharmacol. Exp. Ther., 313: 1217-1222.
CrossRef  |  PubMed  |  Direct Link  |  

4:  Barger-Lux, M.J., K.M. Davies and P.R. Heaney, 2005. Calcium supplementation does not augment bone gain in young women consuming diets moderately low in calcium. J. Nutr., 135: 2362-2366.
PubMed  |  Direct Link  |  

5:  Karppanen, H., R. Pennanen and L. Passinen, 1978. Minerals, coronary heart disease and sudden coronary death. Adv. Cardiol., 25: 9-24.
PubMed  |  Direct Link  |  

6:  Pak, C.Y.C., J.A. Harvey and M.C. Hsu, 1987. Enhanced calcium bioavailability from a solubilized form of calcium citrate. J. Clin. Endocrinol. Metab., 65: 801-805.
CrossRef  |  PubMed  |  Direct Link  |  

7:  Recker, R.R., 1981. Continuous treatment of osteoporosis: Current status. Orthop Clin. North Am., 12: 611-627.
PubMed  |  Direct Link  |  

8:  Seelig, M.S., 1982. Magnesium requirements in human nutrition. Med. Soc., 79: 849-850.
PubMed  |  Direct Link  |  

9:  Van Dokkum, W., V. De la Gueronniere, G. Schaafsma, C. Bouley, J. Luten and C. Latge, 1996. Bioavailability of calcium of fresh cheeses, enteral food and mineral water: A study with stable calcium isotopes in young adult women. Br. J. Nutr., 75: 893-903.
PubMed  |  Direct Link  |  

10:  Esashi, T., 1992. Calcium and magnesium. Rinsho Eiyo. Clin. Nutr., 81: 288-294.

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