Pakistan Journal of Biological Sciences
Year: 2006 | Volume: 9 | Issue: 1 | Page No.: 84-87
ABSTRACT
Three homogentisic acid derivatives, namely methyl 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetate (1), 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetic acid (2), methyl 2-(1`β-geranyl-5`β-hydroxy-4`β-methoxy-2`-oxocyclohexyl)acetate (3), isolated from the leaves of Glossocalyx brevipes, were screened for antisalmonellal activity using both agar diffusion and broth dilution techniques. Only compound 2 showed significant antimicrobial activity against Salmonella typhi (26 mm), Salmonella paratyphi A (23 mm) and Salmonella paratyphi B (22 mm). The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were 10 and 80 μg mL-1, respectively, against all the three bacteria strains used. These data support the use of Glossocalyx brevipes in anti-typhoid preparations.
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How to cite this article
Donatien Gatsing, James A. Mbah, Ibrahim H. Garba, Pierre Tane, Pierre Djemgou and Bridget F. Nji-Nkah, 2006. An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae). Pakistan Journal of Biological Sciences, 9: 84-87.
DOI: 10.3923/pjbs.2006.84.87
URL: https://scialert.net/abstract/?doi=pjbs.2006.84.87
DOI: 10.3923/pjbs.2006.84.87
URL: https://scialert.net/abstract/?doi=pjbs.2006.84.87
REFERENCES
- Mbah, J.A., P. Tane, B.T. Ngadjui, J.D. Connolly, C.C. Okunji, M.M. Iwu and B.M. Schuster, 2004. Antiplasmodial agents from the leaves of Glossocalyx brevipes. Planta Med., 70: 437-440.
Direct Link - Montgomery, T.C., A.J. Freyer, H. Guinandeau, M. Shama, M.O. Fagbule, G. Olatunji and Z. Gbile, 1985. (+)-N-Methyllaurotetanine β-N-oxide from Glossocalyx brevipes. J. Nat. Prod., 48: 833-834.
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