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Research Article

Different Concentration Selenium-modulated Action on Rat Dorsal Root Ganglion Neurons

Tong-Han Lan and Xian-Ming Liu
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In present study, a concentration-dependent effect of Selenium on rat dorsal root ganglion neurons was characterized using whole-cell patch-clamp recording. Among about 52% of the cells tested, the amplitude of membrane ion current increased, after administration of Selenium. In the presence of 0.001 nM (nanomolar) Selenium, the reversal potential and membrane conductance were changed. The above-mentioned actions suggest that selenium may play a physiological role in regulating the excitatory action on mammalian neurons.

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  How to cite this article:

Tong-Han Lan and Xian-Ming Liu , 2005. Different Concentration Selenium-modulated Action on Rat Dorsal Root Ganglion Neurons. Pakistan Journal of Biological Sciences, 8: 855-859.

DOI: 10.3923/pjbs.2005.855.859


1:  Rayman, M.P., 2000. The importance of selenium to human health. Lancet, 356: 233-241.
CrossRef  |  PubMed  |  Direct Link  |  

2:  Burk, R.F. and K.E. Hill, 1993. Regulation of selenoproteins. Ann. Rev. Nutr., 13: 65-81.
CrossRef  |  PubMed  |  Direct Link  |  

3:  Takahashi, K. and H.J. Cohen, 1986. Selenium-dependent glutathione peroxidase protein and activity: Immunological investigations on cellular and plasma enzymes. Blood, 68: 640-645.

4:  Ursini, F., M. Maiorino and C. Gregolin, 1985. The selenoenzyme: Phospholipid hydroperoxide glutathione peroxides. Biochem. Biophys. Acta, 839: 295-308.

5:  Burk, R.F., K.E. Hill, R. Read and T. Bellew, 1991. Response of rat selenoprotein P to selenium administration and fate of its selenium. Am. J. Physiol., 261: 26-30.

6:  Hom, D.G., D. Jiang, E. Hong, J.Q. Mo and J.K. Anderson, 1997. Elevated expression of glutathione peroxidase in PC12 cells results in protection against methamphetamine but not MPTP toxicity. Mol. Brain Res., 46: 154-160.

7:  Iwanier, K. and B.A. Zachara, 1995. Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. J. Androl., 16: 441-447.
Direct Link  |  

8:  Euybov, I.Z., N.M. Shirinov and R.I. Rzaev, 1983. Effect of selenium on reproductive organs and fertility of animals. Trud Azerbaizh Nauch Inst. Vet., 28: 103-105.

9:  Itzhak, Y., C. Gandia, P.L. Huang and S.F. Ali, 1998. Resistance to neuronal nitric oxide synthase deficient mice to methamphetamine-induced dopaminergic neurotoxicity in vivo. J. Pharmacol. Exp. Therapeut., 284: 1040-1047.

10:  Watnabe, C. and T. Suzuki, 1986. Sodium selenite-induced hypothermia in mice: Indirect effect for a neural effect. Toxicol. Applied Pharmacol., 86: 372-379.

11:  Westermarck, T. and P. Santavouri, 1984. Principles of antioxidant therapy in neuronal ceroid lipofuscinoisis. Med. Biol., 62: 148-151.

12:  Hong-Zhen, H. and L. Zhi-Wang, 1996. Substance P potentiates ATP-activated currents in rat primary sensory neurons. Brain Res., 739: 163-168.

13:  Hong-Zhen, H. and L. Zhi-Wang, 1997. Modulation by adenosine of GABA-activated current in rat dorsal root ganglion neurons. J. Physiol., 501: 67-75.
Direct Link  |  

14:  Hu, H.Z., Z.W. Li and J.Q. Si, 1997. Evidence for the existence of substance P autoreceptor in the membrane of rat dorsal root ganglion neurons. Neuroscience, 77: 535-541.
PubMed  |  Direct Link  |  

15:  Lan, T.H., B.Q. Xu, H.J. Yuan and J.R. Lin, 2003. Rescaled range analysis applied to the study delayed rectifier potassium channel kinetics. Biophys. Chem., 106: 67-74.
CrossRef  |  

16:  Lan, T.H., X.M. Liu, H.J. Yuan and J.R. Lin, 2003. Gating kinetics of potassium channel in rat dorsal root ganglion neurons analyzed with fractal model. Biophys. Chem., 106: 203-209.
PubMed  |  Direct Link  |  

17:  Lan, T.H., G.H. Li, Z.W. Li and J.R. Lin, 2003. Stimulatory effects of NMDA on intracellular Ca2+ nonlinear kinetic model in rat dorsal root ganglion neurons. Chinese J. Biomed. Eng., 1: 1-13.

18:  Lan, T.H. and L. Jia-Rui, 2003. Rescaled range analysis applied to the study on intracellular Ca2+. Pak. J. Biol. Sci., 6: 925-931.
CrossRef  |  Direct Link  |  

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