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Research Article
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Different Concentration Selenium-modulated Action on Rat Dorsal Root Ganglion
Neurons |
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Tong-Han Lan
and
Xian-Ming Liu
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ABSTRACT
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In present study, a concentration-dependent effect of Selenium on
rat dorsal root ganglion neurons was characterized using whole-cell patch-clamp
recording. Among about 52% of the cells tested, the amplitude of membrane ion
current increased, after administration of Selenium. In the presence of 0.001
nM (nanomolar) Selenium, the reversal potential and membrane conductance were
changed. The above-mentioned actions suggest that selenium may play a physiological
role in regulating the excitatory action on mammalian neurons.
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