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Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 5 | Page No.: 740-743
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Research Article

Comparative Efficacy of Two Medicinal Plant Extracts and an Antibiotic on Wound Healing

M.M. Alam, S.A. Islam, Y. Mohammed, N.S. Juyena and M.A. Hashim

ABSTRACT

The present investigation was carried out to study the comparative efficacy of two medicinal plant extracts and an antibiotic on wound healing. This was conducted on 18 female goats at BAU Veterinary Clinic. Infiltration anesthesia was performed with 2% lignocaine hydrochloride (Jasocaine®, Reneta Pharmaceuticals Ltd.) at the site of operation on lumber region. Four experimental skin wounds, two in either side of the midline plane at the lumbar region were made, each was of 2.5 cm length and 0.5 cm depth. The experimental animals were studied under 6 Groups. A series of 50 and 30% extracts of border plant (Aerva sanguinolenta), thankuni plant (Centella asiatica), antibiotic (Pronapen®) and saline were used in this experiment and these were applied twice daily to each wound. All extracts seemed to be effective for rapid healing. A 50% extracts of border plant showed the best result where healing time was 14 days whereas in antibiotic it took 16 days. In contrast more time (20 days) was required for control group. Clinical feature revealed exudation, scab formation, redness and other routine changes. Redness was more prominent in control and antibiotic treated groups compare to other groups on day 3 of wounding. Thus both border and thankuni plant extracts are very much effective for wound healing and can be applied instead of antibiotic.
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