The study was conducted to evaluate the macroscopic changes of burn wounds healing progress as a response to various types of honey applied topically. A total of 42 male, Sprague Dawley rats (weight 200-300 g) were used in this study. The animals were randomly divided into seven experimental groups consisted of 6 animals for each group. Macroscopic changes of the burn wounds healing progress were evaluated at day 0 post burned and subsequently at days 3, 7, 14, 21 and 28 post burned. To determine the rate of wound contraction the changes in the size of burn wounds were traced by measuring the diameter of the wound area both longitudinally and transversely across the body length using a ruler. The change in wound diameter at various time intervals was calculated as the percentage of wound area that had healed. The results obtained from this study indicated that topical application of Manuka and Melaleuca (Gelam) honeys significantly stimulated the rate of burn wound healing as assessed by increased in the rate of wound contraction and from the observation of gross appearances.
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M.Z. Rozaini, A.B.Z. Zuki, M.M. Noordin, Y. Norimah and A. Nazrul Hakim, 2005. Macroscopic Evaluation of Burn Wounds Healing Progress Treated with Different Types of Honey. Pakistan Journal of Biological Sciences, 8: 672-678.
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