Subscribe Now Subscribe Today
Research Article

Effect of Oral Administration of Aqueous Extract of Khaya senegalensis Stem Bark on Phenylhydrazine-induced Anaemia in Rats

F.S. Sanni , S. Ibrahim , K.A.N. Esievo and S. Sanni
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

The anti-anaemic effect of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia was carried out in rats. Induction of anaemia was conducted using phenylhydrazine hydrochloride at a dose of 750 mg kg-1 body weight. In vivo investigation showed that oral daily dose of 300 mg kg-1 body weight of the bark aqueous extract of K. senegalensis in rats administered simultaneously with the phenylhydrazine produced significant (p<0.05) anti-anaemic effect probably by protecting the red blood cells against destruction by phenylhydrazine. However, the same oral dose did not show any significant curative effect (p>0.05) after the induction of anaemia using phyenylhdrazine hydrochloride. The phytochemical screening of the aqueous extract of the stem bark of K. senegalensis indicate the presence of carbohydrate, saponin, glycosides and tannins. Also present are important mineral elements necessary for the development and functioning of the body. These include calcium, magnesium, zinc, iron, copper, potassium, and sodium. This study showed that Khaya senegalensis has an anti-anaemic effect.

Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

  How to cite this article:

F.S. Sanni , S. Ibrahim , K.A.N. Esievo and S. Sanni , 2005. Effect of Oral Administration of Aqueous Extract of Khaya senegalensis Stem Bark on Phenylhydrazine-induced Anaemia in Rats. Pakistan Journal of Biological Sciences, 8: 255-258.

DOI: 10.3923/pjbs.2005.255.258


AOAC., 1980. Official Methods of Analysis. 13th Edn., Association of Official Analytical Chemist, Washington, DC., USA., pp: 56-132.

Adesina, S.K., 1983. Chemical examination of Khaya senegalensis. Fitoterapia, 3: 41-41.

Aguwa, C.N. and G.C. Mittal, 1983. Abortifacient effects of the roots of Momordica angustisepala. J. Ethnopharmacol., 7: 169-173.
CrossRef  |  Direct Link  |  

Akinkugbe, O.F., 1991. Anaemia the perils of plenty. Clin. Pharm. Herbal Med., 8: 15-15.

Allen, S.T., 1974. Chemical Analysis of Ecological Material. Blackwell Scientific Publication, New York, pp: 313.

Awosika, F., 1991. Local medicinal plants and the health of consumers. Clin. Pharm. Herbal Med., 9: 28-28.

Bowman, W.C. and M.J. Rand, 1980. Textbook of Pharmacology. 2nd Edn., Blackwell Scientific Publications, Oxford, UK.

Ferrali, M., C. Signorini, L. Ciccoli and M. Comporti, 1992. Iron release in erythrocytes exposed to oxidising agents Biochem. J., 285: 295-301.
Direct Link  |  

Harris, P.F. and J.K. Kugler, 1971. Unusual monoclonal cell in guinea pig peripheral blood during anaemia. J. Anat., 108: 1-1.

Kaey, R.W.J., C.F.A. Onochie and D.P. Sanfield, 1964. Meliacea Nigerian Trees. Vol. II, University of Ibadan Press, Ibadan, Nigeria, pp: 257-282.

Kerharo, J., 1969. Current interest in cail cedrat (Khaya senegalensis a Juss). Med. Afr. Noire, 16: 735-735.

McCune, B. and M. Mefford, 1999. Multivariate Analysis of Ecological Data Version 4.17. M.J.M Software. 1st Edn., Glenden Beach, Oregon, USA., pp: 233.

Nwafor, P.A., K.D. Effraim, H.Z. Garuba, T.W. Jacks and E. Emagun, 1995. Gastroprotective extract of Khaya senegalensis bark on indomethacin-induced gastric ulceration in rats. Proceedings of the 5th NAAP Scientific Conference, pp: 49-52.

Olayinka, A.O., 1992. Preliminary phytochemical screening and microscopical studies of the leaf and bark of Khaya senegalensis a Juss. Proceedings of the 2nd NAAP Scientific Conference, (NSC'92), University of Jos, Jos, Nigeria, pp: 58-68.

Ong, H.C., 1973. Anaemia in pregnancy in an aborigine population. Med. J. Malaya, 28: 22-22.

Orna, N., 1991. Iron deficiency anaemia. Clin. Pharm. Herb. Med., 7: 12-16.

Oyenuga, V.A., 1968. Nigerian Foods and Feeding Stuff Their Chemistry and Nutrition Value. 3rd Edn., Ibadan University Press, Ibadan, Nigeria, pp: 1-70.

Richard, H., 1978. Chinese Herbal Medicine Ancient Art and Modern Science. Shocker Brook, New York, pp: 49-52.

Schalm, O.W., N.C. Jain and G.H. Carroll, 1975. Veterinary Hematology. 3rd Edn., Lea and Febiger, Philadelphia, PA, USA., ISBN-13: 9780812104707, Pages: 807.

Smith, E.C.G., 1980. Haematological effect of drug theraphy. Clin. Haematol., 9: 572-572.

Spector, W., 1956. Toxicology. Vol. I, Sander, Philadelphia, USA., pp: 130-131.

Taylor, D.A.H., 1969. Extractives from swieten mahogani. Chem. Commun., 2: 58-58.

Thomas, M.D., 1986. Blood Cells. 2nd Edn., Wiley Medical Publication, London, pp: 842-843.

Trease, G.E. and W.C. Evans, 1984. Pharmacognosy. Bailliere Tindall, London, pp: 184-186.

Trease, G.E. and W.C. Evans, 1992. Pharmacognosy. Bailliere Tindall, London, pp: 395-398.

©  2020 Science Alert. All Rights Reserved