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Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 11 | Page No.: 1623-1627
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Research Article

Effect of Anemia on Left Ventricular Hypertrophy and Ejection Fraction in Maintenance Hemodialysis Patients

M.D. Azar Baradaran and M.D. Hamid Nasri

ABSTRACT

The present research aimed to consider the adverse effects of amenia on left venrticular function and structure in dialysis patients due to End-Stage Renal Disease (ESRD) undergoing regular hemodialysis. For patients complete blood count, serum Iron, total iron binding capacity and serum ferritin were measured. On the basis of septal thickness, the patients stratified into, no Left Ventricular Hypertrophy (LVH), mild, moderate and severe LVH. In this study a significant difference of Haemoglobin (Hb) and Haematocryt (Hct ) between males and females with more values in the female group and a significant inverse correlation of serum ferritin with hemoglobin levels were found. A significant inverse correlation of Left Ventricular (LV) ejection fraction with duration of hemodialysis treatment was observed. A near significant inverse correlation of LV ejection fraction with serum ferritin was found, also a significant inverse correlation of LVH with LV ejection fraction was observed too. In present study female dialysis patients had more prominent anemia than males which implies more attention to anemia treatment in this group. We showed an inverse association of LV ejection fraction with serum ferritin. We also showed that duration of hemodialysis treatment have an adverse effect on progression of LVH. We concluded that anemia in conjunction with other important factors like duration of dialysis could aggravate the hypertrophy of LV.
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