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Pakistan Journal of Biological Sciences

Year: 2005 | Volume: 8 | Issue: 10 | Page No.: 1424-1429
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Research Article

Effect of Aqueous Extract of Prasium majus`s L. Leaves on Water and Electrolytes Transport in Rat Intestine

F. Khemiss, D. Saidane and A.A. Moshtaghie

ABSTRACT

The major aim of this investigation was to examine the effect of aqueous extract of Prasium majus`s L. leaves (AEPML) on intestinal influx of water and electrolytes by Everted Gut Sac (EGS). Four segments of rat intestine were detected and used (duodenum, jejunum, ileum and colon). The extract of the plant was used with two concentrations,8 and  16 g L-1, respectively. The results obtained showed that AEPML provoke; firstly  an  inhibition  of  water  secretion by   different  parts  of  EGS, but decrease was only significant at the ileum (p<0.05).Secondly electrolytes fluxes were also sensitive to the addition of AEPML.On  the  other hand  for  Na+ influx,we noted an inhibition of the secretion at the duodenum and the colon (p < 0.01) with the dose 8 g L-1, while for Cl-, influx this inhibition was only registered at the colon (p<0.01) with the dose 8 g L-1. For K+ influx, AEPML induced rather a significant reabsorption at the duodenum, the jejunum and the colon  (p < 0.01) hile at the ileum the reabsorption increased. This was only significant with the dose 16 g L-1.It may be concluding that the heterogeneity of the gastrointestinal tract in response to numerous factors which are able to affect homeostasis of water and electrolytes. AEPML might have an antisecretory function on water Na+ and Cl- and an absorptive function on K+.
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