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Hepatoprotective Activity of Hibiscus cannabinus (Linn.) Against Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats



Gabriel A. Agbor , Julius E. Oben , Blaise Nkegoum , Jean Pierre Takala and Jeanne Y. Ngogang
 
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ABSTRACT

In the present study the hepatoprotective activity of a daily oral dose (1.6 g kg-1) of aqueous leaf extract of H. cannabinus was investigated over a two week period in albino rats. Liver damage in rats was induced using Carbon tetrachloride (CCl4) and Paracetamol (PCM). This was confirmed by increased plasma transaminases activities, total bilirubin concentration and Thiobarbituric Acid Reactive substance (TBRs, a measure of lipid peroxidation). Histopathological examinations substantiated this liver damage with fatty deposits, severe inflammation and severe necrosis. The aqueous leaf extract of H. cannabinus showed a significant (p<0.05) hepatoprotective activity against this damage in lowering the plasma transaminases and bilirubin concentration significantly (p<0.05). Absents of necrosis in liver cells of rats pretreated with extract indicated a protective effect. The extract also inhibited lipid peroxidation, suggesting a possible mechanism of action. The results obtained confirm the hepatoprotective activity of H. cannabinus.

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  How to cite this article:

Gabriel A. Agbor , Julius E. Oben , Blaise Nkegoum , Jean Pierre Takala and Jeanne Y. Ngogang , 2005. Hepatoprotective Activity of Hibiscus cannabinus (Linn.) Against Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats. Pakistan Journal of Biological Sciences, 8: 1397-1401.

DOI: 10.3923/pjbs.2005.1397.1401

URL: https://scialert.net/abstract/?doi=pjbs.2005.1397.1401

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