Subscribe Now Subscribe Today
Research Article
 

Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis



Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

Human coagulation factor V serves as a cofactor for factor X in thrombin formation. Generation of thrombin leads to fibrin and clot formation. In this study 65 patients were selected with venous thrombosis. Patients with a positive Protein C resistance were chosen and screened genetically by Conformation Sensitive Gel Electrophoresis (CSGE) for the presence of factor V mutations, the suspected mutations were sequenced. Three new mutations were found as follows, Met 385 thr, Met 1736 Val and Lys 386 Lys. Present study shows factor V mutations leading to thrombosis that have been never reported in Iran

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Abbas Hajifathali , Bahram Kazemi , Aliakbar Pourfathollah , Ghasem Rastegar Lari and Rouzbeh Chegeni , 2005. Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis. Pakistan Journal of Biological Sciences, 8: 1272-1274.

DOI: 10.3923/pjbs.2005.1272.1274

URL: https://scialert.net/abstract/?doi=pjbs.2005.1272.1274

REFERENCES
1:  Chan, W.P., C.K. Lee, Y.L. Kwong, C.K. Lam and R. Liang, 1998. A novel mutation of Arg 306 of factor V gene in Hong Kong Chinese. Blood, 91: 1135-1139.
Direct Link  |  

2:  Koster, T., F. Rosendaal, H. de Ronde, E. Briet, J. Vandenbrouke and R. Bertina, 1993. Venous thrombosis due to poor anticoagulant response toactivated protein C: Leiden Thrombophilia study. Lancet, 342: 1503-1503.

3:  Svensson, P. and B. Dahlback, 1994. Resistance to activated proteion C as a basis for venous thrombosis. N. Eng. J. Med., 330: 517-522.
PubMed  |  Direct Link  |  

4:  Zoller, B., P. Svensson, X. He and B. Dahlback, 1994. Identification of thesame factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J. Clin. Invest., 94: 2521-2521.
Direct Link  |  

5:  Voorberg, J., J. Roelse, R. Koopman, H. Buller, F. Berends and J.T. Cate et al., 1994. Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet, 343: 1535-1536.
PubMed  |  

6:  Greengard, J., X. Sun, X. Xu, J. Fernandez, J. Griffin and B. Evatt, 1994. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet, 343: 1361-1362.
Direct Link  |  

7:  Bertina, R.M., B.P.C. Koeleman, T. Koster, F.R. Rosendaal and R.J. Dirven et al., 1994. Mutation in blood coagulation factor associated with resistance to activated protein C. Nature, 369: 64-67.

8:  Dahlback, B., 1994. Physiological anticoagulation: Inherited resistance to activated protein C and venous thromboembolism. J. Clin. Invest., 94: 923-927.
CrossRef  |  

9:  Jorquera, J., J. Montoro, M. Fernandez, J.A. Aznar and J. Aznar, 1994. Modified test for activated protein C resistance. Lancet, 344: 1162-1163.
PubMed  |  

10:  McPherson, M.J. and S.G. Moller, 2000. PCR. 1st Edn., BIOS Scientific Publishers, Oxford, UK.

11:  Ganguly, A., 2002. An update on conformation sensitive gel electrophoresis. Human Mut., 19: 334-342.
Direct Link  |  

12:  Nicholaes, G.A.F. and B. Dahlback, 2003. Activated Protein C resistance (FV Leiden) and thrombosis: Factor V mutations causing hypercoagulable states. Hematol. Oncol. Clin. N. Am., 17: 37-61.
PubMed  |  

©  2021 Science Alert. All Rights Reserved