Subscribe Now Subscribe Today
Research Article
 

Quantitative Examination of Aerobic Bacteria and Fungi in Locally Available Antacid Suspension and Possible Contamination by Specified Bacteria



Mahboob Hossain , Shamim Ara and Mohammed Zakiur Rahman
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

The microbiological status of liquid antacid suspension of 20 pharmaceutical industries of Bangladesh were studied. Aerobic viable microbial count of 27 (75%) out of 36 samples studied were found to exceed the USP limit. Viable microbial count varied between less than 102 CFU mL-1 and greater than 106 CFU mL-1. In 11 (30%) samples of 8 companies the total aerobic microbial count was more than 103 CFU mL-1. Microbial counts of two large reputed pharmaceutical companies were 1000 fold higher than those of some small companies. None of the samples contained Escherichia coli and Salmonella spp. Out of 36 samples 1 (2.5%) of the 2 samples of one company having different manufacturing date contained Pseudomonas aeruginosa and both samples (5%) having different manufacturing date of another large company contained Staphylococcus aureus. No significant correlation between pH deviation and contamination by microbes was observed.

Services
Related Articles in ASCI
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Mahboob Hossain , Shamim Ara and Mohammed Zakiur Rahman , 2004. Quantitative Examination of Aerobic Bacteria and Fungi in Locally Available Antacid Suspension and Possible Contamination by Specified Bacteria. Pakistan Journal of Biological Sciences, 7: 2014-2017.

DOI: 10.3923/pjbs.2004.2014.2017

URL: https://scialert.net/abstract/?doi=pjbs.2004.2014.2017

REFERENCES

1:  Elizabeth, P. R., 1971. Pseudomonas aeruginosa contamination of liquid antacids: A survey. J. Pharm. Sci., 60: 604-605.
CrossRef  |  

2:  Baird, R.M. and P.S. Petris, 1981. A study of microbiological contamination of oral medicaments. Pharm. J., 266: 10-11.

3:  Kallings, L.O., O. Ringertz and L. Silverstolpe 1996. Microbial contamination of medical preparations. Acta Pharmaca Succica., 3: 219-228.
PubMed  |  

4:  Hoq, M.M., M.B. Syeda and D.J. Gomes, 1991. Development of appropriate preservative system for liquid antacid: I. Bacterial contaminants in antacid samples. Bangladesh J. Microbiol., 8: 5-10.

5:  Malik, A.K.M., A.S.M. Alam, S.K. Gosh, M.A. Hossain and A.B. Siddique, 1991. Analytical evaluation of locally available pharmaceutical products, Part 1. Analysis of some antacid preparations for their active ingredients and for possible contamination by trace metals and microorganisms. J. Bangladesh Chem. Soc., 4: 87-92.

6:  Anonymous, 1998. British pharmacopoeia. Test Microbial Contam., 2: A243-A253.

7:  Gilbert, P. and N. Wright, 1987. Non-plasmidic Resistance Towards Preservatives of Pharmaceutical Products. In: Preservatives in the Food, Pharmaceutical and Environmental Industries, Board, R.G., M.C. Allwood and J.G. Banks (Eds.). Blackwell Scientific Publication, Oxford, pp: 255

8:  Rawlins, E.A., 1996. Microbial Contamination, Control and Sterility Testing: Bentleys Textbook of Pharmaceutics. 8th Edn., Bailleere Tindall and Cox Ltd., London, pp: 546

9:  Hugo, W.B. and A.D. Rusell, 1983. Pharmaceutical Microbiology. 3rd Edn., Blackwell Scientific Publications, Oxford, pp: 223, 345, 347

©  2021 Science Alert. All Rights Reserved