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Research Article
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Heating and Chemical Denaturation of Egg Albumin Matrix and its Effect on the Release Kinetics of Theophylline from Tablets |
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Sharif Md. Shaheen,
Mamunur Rashid ,
Md. Anwar ul Islam
and
Reza Ul Jalil
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ABSTRACT
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Egg albumin (EA) matrix tablets containing theophylline (TH) were prepared by
direct compression using 13 mm die and punch and a hydraulic press (3 ton compressor)
after simple dry mixing of these two ingredients. Chemical denaturation of EA
using both glutaraldehyde and formaldehyde as cross linking agents showed a remarkable
decrease in TH release rate from matrix tablets when compared with untreated and
heat denatured TH matrix tablets. The release rate was further reduced when mutual
chemical and heating denaturations were applied. In all cases release mechanism
was square root of time dependent indicating diffusion type release. It was found
that heating for 1 h at only 65°C was enough to produce the release retardation
effect, whereas, heating beyond 65°C (up to 105°C) had no significant effect on
the release rate. Heat denatured tablets also showed a Higuchian release pattern.
The release rate of heat denatured (at 105°C for 1 h) matrices were slightly decreased
than the unheated tablets. However the duration of heating (20 to 100 min)
had no significant effect on the release rate.
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