Subscribe Now Subscribe Today
Research Article
 

Physiological Effect of LD50 of Walterinnesia aegyptia Crude Venom on Rat Metabolism Over Various Periods of Time



Ibrahim and A. Al-Jammaz
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
ABSTRACT

Serum physiological parameters are important in assessing the vital organ functions following envenomation. The effects of LD50 of the crude venom members of the snake family Elapidae, Walterinnesia aegyptia on the serum physiological parameters of white rats have been evaluated over various periods of time. The snake venom has induced a reduction in serum total protein, total albumin, uric acid, cholesterol, phosphorus, and calcium levels, as well as, the activities of LDH and AST. Serum urea, total bilirubin, creatinine, glucose, and triglycerides levels, as well as, the activities of ALT, ALP, AMY and AST were significantly increased in some of the envenomated rat groups. Thus, it appeared that W. aegyptia crude venom can cause time dependent disturbances of some of the vital organs of envenomated rats.

Services
Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

 
  How to cite this article:

Ibrahim and A. Al-Jammaz , 2001. Physiological Effect of LD50 of Walterinnesia aegyptia Crude Venom on Rat Metabolism Over Various Periods of Time. Pakistan Journal of Biological Sciences, 4: 1429-1431.

DOI: 10.3923/pjbs.2001.1429.1431

URL: https://scialert.net/abstract/?doi=pjbs.2001.1429.1431

REFERENCES
1:  Abdel-Nabi, I.M., 1993. Effect of crude Cerastes cerastes venom and fraction B on the clinical biochemical parameters of white rat. J. Egypt. Ger. Soc. Zool., 10: 315-326.

2:  Abdel-Nabi, I.M., A. Raafat and H.I. El-Shamy, 1997. Biological effects of intraperitoneal injection of rats with the venom of the snake Echis carinatus. Egypt. J. Zool., 29: 195-205.

3:  Al-Jammaz, I., 1995. Effects of the venom of Walterinnesia aegyptia and Echis coloratus on solute levels in the plasma of albino rats. J. King Saud Univ. Sci., 1: 63-69.

4:  Al-Jammaz, I., M.K. Al-Sadoon, M.A. Attia and A. Fahim, 1992. Effect of Walterinessia aegyptia venom on serum, tissue metabolites and some enzyme activities in male albino rats I. Enzyme activities. Ain Shams Sci. Bull., 30: 207-222.

5:  Al-Jammaz, I., M.K. Al-Sadoon and A. Fahim, 1999. Effect of LD5o dose of echis coloratus venom on serum and tissue metabolites and some enzymes of male albino rats. J. King Saud Univ. Sci., 11: 61-68.
Direct Link  |  

6:  Al-Sadoon, M.K., 1989. Survey of the reptilian fauna of the Kingdom of Saudi Arabia. I. The snake fauna of central region. J. King Saud Univ. Sci., 1: 53-69.

7:  Aung-Khin, M., 1978. Histological and ultrastructural changes of the kidney in renal failure after viper envenomation. Toxicon, 16: 71-75.

8:  Chugh, K.S., B.K. Aikat, B.K. Sharma, S.C. Dash, M.T. Mathew and K.C. Das, 1975. Acute renal failure following snakebite. Am. Trop. Med. Hyg., 24: 692-697.

9:  El-Asmar, M.F., R.M. Farag, S. Shoukry and I.R. El-Shimi, 1979. Effect of scorpion Leivrus quinquestriatus H and E venom on lipid metabolism. Toxicon, 17: 279-283.

10:  Fahim, A., 1998. Biological effects of the viper B. arietans, crude venom on albino rats. Egypt. J. Zool., 30: 35-54.

11:  Lee, C.Y., C.C.T.H. Chiu, P.J.S. Chiu, T.C. Tseng and S.Y. Lee, 1968. Pharmacological properties of cadiotoxin isolated from Formosan Cobra venom. Arch. Pharm. Exp. Pathol., 229: 260-273.

12:  Marsh, N., D. Gattullo, P. Pagliaro and G. Losano, 1997. The Gaboon viper and Bitis gabonica: Hemorrhagic, metabolic, cardiovascular and clinical effects of the Venom. Life Sci., 61: 763-769.

13:  Meier, J. and K. Stocker, 1991. Effects of snake venoms on hemostasis. Toxicology, 21: 171-182.
CrossRef  |  Direct Link  |  

14:  Mohamed, A.H., M. El-Serougi and A. Kamel, 1964. Effects of Walterinessia ageypta venom on blood sodium, potassium and catecholamines and urine 17-ketosteroids. Toxicon, 2: 103-107.
CrossRef  |  Direct Link  |  

15:  Mohamed, A.H., M.S. El-Serougi and A.M. Kamel, 1965. Effect of Walterinnesia aegyptia venom on blood glucose in diabetic animals. Toxicon, 3: 163-165.

16:  Mohamed, A.H., S. Foaud, F. Abbas, A. Abdel-Aal and A.A. Baset et al., 1980. Metabolic studies of the Egyptian and allied African snake venoms. Toxicon, 18: 381-383.

17:  Mohamed, A.H., S. Fouad, S. El-Aasar, A.M. Salem and A. Abdel-Aal et al., 1981. Effects of several snake venoms on serum and tissue transaminases, alkaline phosphatase and lactate dehydrogenase. Toxicon, 19: 605-609.
CrossRef  |  Direct Link  |  

18:  Raab, W. and E. Kaiser, 1966. Nephrotoxic action of snake venoms. Mem. Inst. Butantan, 33: 1017-1027.

19:  Sant, S.M. and N.M. Purandare, 1972. Autopsy study of cases of snake bite with special reference to the renal lesions. J. Postgrad. Med., 18: 181-188.
PubMed  |  

20:  Sitprija, V. and V. Boonpucknaving, 1977. The kidney in tropical snake bite. Clin. Nephrol., 8: 377-383.

21:  Sitprija, V., R. Suvanpha, C.S.P. Chusil and K. Tungsanga, 1982. Acute interstitial nephritis in snake bite. Am. J. Trop. Hyg., 31: 408-410.

22:  Tilbury, C.R., M.M. Madkour, D. Saltissi and M. Suleiman, 1987. Acute renal failure following the bite of Burton's carpet viper Echis coloratus Gunther in Saudi Arabia: Case report and review. Saudi Med. J., 8: 87-95.
Direct Link  |  

23:  Warrell, D.A., R.E. Phillips, D.G. Theakston, Y. Galigedara and D.T. Abeysekra et al., 1989. Neurotoxic envenoming by Indian krait (Bungarus caerules), Cobra (Naja naja) and Russells viper (Vipera tusselli, pulchella) in Anuradhapura. Toxicon, 27: 75-87.

©  2020 Science Alert. All Rights Reserved