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Additional Possibility of Data Analysis of Enzyme Inhibition and Activation. 8. A Choice of the Equations for Calculation of the Initial Reaction Rates vi and va in Enzyme Inhibition and Activation

V.I. Krupyanko

The equations for calculation of initial rates of the associative, Ivi type and catalytic, IIIi type, of enzyme inhibition are most frequently used in practice of calculation the initial rates of inhibited (vi) enzymatic reactions (Appendix B1, Eq. B4 and B3). In some cases these equations are used with arbitrary modifications that may lead to incorrect calculation of respective parameters of reactions. Now the equations for calculation of initial rates (vi) and (va) have been deduced for all seven types of inhibited (Ii, Iii, IIIi, IVi, Vi, VIi, VIIi) and seven types of activated (Ia, IIa, IIIa, IVa, Va, VIa, VIIa) enzymatic reactions and it need to discuss the rule of choice (and conditions of applicability) of equation for processing experimental data of each these types of enzymatic reactions. Examples of choice the equations for calculation of the initial reaction rates vi and va (and ki, ka) constants are given.

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V.I. Krupyanko , 2007. Additional Possibility of Data Analysis of Enzyme Inhibition and Activation. 8. A Choice of the Equations for Calculation of the Initial Reaction Rates vi and va in Enzyme Inhibition and Activation . Journal of Biological Sciences, 7: 506-513.

DOI: 10.3923/jbs.2007.506.513


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