Asmah Rahmat
Department of Nutrition and Health Science, Faculty of Medicine and Health Science, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia
Bibi Rohaniza Baharudin
Department of Nutrition and Health Science, Faculty of Medicine and Health Science, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia
Mohd Fadzelly Abu Bakar
Department of Nutrition and Health Science, Faculty of Medicine and Health Science, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia
ABSTRACT
The antidiabetic effect of crude extract of Andrographis paniculata leaves were studied on normal and alloxan induced hyperglycaemic rats. Oral administration of Andrographis paniculata leaf extract (10 mg kg-1 body weight) for 8 weeks resulted in significant reduction in glucose level as well as increased in body weight in alloxan induced hyperglycaemic rats but not in normal rats, which clearly shows the antidiabetic properties of Andrographis paniculata crude extract. The effect of the extract at dose 10 mg kg-1 body weights was more effective than tested hypoglycaemic agent (glibenclamide) at dose 10 mg kg-1 body weights in restoring the values of these parameters.
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How to cite this article
Asmah Rahmat, Bibi Rohaniza Baharudin and Mohd Fadzelly Abu Bakar, 2006. Effects of Andrographis paniculata Crude Extract in Normal and Alloxan Induced Hyperglycaemic Rats. Journal of Biological Sciences, 6: 92-95.
DOI: 10.3923/jbs.2006.92.95
URL: https://scialert.net/abstract/?doi=jbs.2006.92.95
DOI: 10.3923/jbs.2006.92.95
URL: https://scialert.net/abstract/?doi=jbs.2006.92.95
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