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The Effects of Thioperamide on the Histamine Level and Histidine Decarboxylase Activity of Mouse Brain



Durdi Qujeq and Rahim Jourjani Daz
 
ABSTRACT

The aim of this study was to determine the effects of thioperamide on the total brain histamine content and histidine decarboxylase activity of mouse brain. Mice (n = 24) was used in this study. The animals were housed six per cage, water and food were allowed. All experimented manipulations were carried out with the animals under ether inhalation anesthesia. Mice were injected with 20 mg kg-1 of thioperamide 30 min and 5 h after IP injection of thioperamide and brains were removed. The brain homogenate was centrifuged and supernatant was obtained. Aliquots were removed for determination of histamine content and HD activity. The florescence was measured at 440 nm with excitation at 360 nm. The HD activity of brain was higher of treated mice (63.8±4.6 nmol mg/protein/min) than in control group (49.1±3.4 nmol mg/protein/min). Treated mice had a statistically significant increase in mean brain histamine level (243.7±7.9 nmol mg/protein) when compared with control group (197.3±8.2 nmol mg/protein). The increase in the histamine content and HD activity in the brain after injection of thioperamide in the brain, may contribute of the stimulate of histidine decarboxylase enzyme by thioperamide.

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  How to cite this article:

Durdi Qujeq and Rahim Jourjani Daz , 2006. The Effects of Thioperamide on the Histamine Level and Histidine Decarboxylase Activity of Mouse Brain. Journal of Biological Sciences, 6: 61-64.

DOI: 10.3923/jbs.2006.61.64

URL: https://scialert.net/abstract/?doi=jbs.2006.61.64

REFERENCES
Acuna, Y., Y. Mathison, H.A. Campos and A. Israel, 1998. Thioperamide a histamine H3 receptor blocker facilitates vasopressor response to footshocks. Inflamm. Res., 47: 109-114.
PubMed  |  

Arrang, J.M., M. Garbarg and C. Schwartz, 1983. Auto inhibition of brain histamine release mediated by a novel class(H3) of histamine receptor. Nature, 302: 832-837.
CrossRef  |  

Detzner, M., M. Kathmann and E. Schlicker, 1994. Time course of the effects of histamine thioperamide and EEDQ on H3 receptors in the mouse brain. Agents Actions, 41: 66-67.
CrossRef  |  

Imaizumi, M. and K. Onodera, 1993. The behavioral and biochemical effects of thioperamide a histamine H3 receptor antagonist in a light dark test measuring anxiety in mice. Life Sci., 53: 1675-1683.
PubMed  |  

Itoh, E., M. Fujimiya and A. Inui, 1998. Thioperamide a histamine H3 receptor antagonist suppresses NPY but not dynorphin a induced feeding in rats. Regul. Pept., 6: 373-376.
Direct Link  |  

Itoh, E., M. Fujimiya and A. Inui, 1999. Thioperamide a histamine H3 receptor antagonist powerfully suppresses peptide YY induced food intake in rats. Biol. Psychiatry, 45: 475-481.
Direct Link  |  

Lapham, J. and G.J. Kilpatrick, 1994. Thioperamide the selective histamine H3 receptorantagonist attenuates stimulant induced locomotor activity in the mouse. Eur. J. Pharmacol., 259: 107-114.
PubMed  |  

Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265-275.
PubMed  |  Direct Link  |  

Meguro, K., K. Yanai, N. Sakai, E. Sakurai, K. Maeyama, H. Sasaki and T. Watanabe, 1995. Effects of thioperamide, a histamine H3 antagonist on the step through passive avoidance response and histidine decarboxylase activity in senescence accelerated mice. Pharmacol. Biochem. Behav., 50: 321-3255.
Direct Link  |  

Nimura, T., K. Maeyama, N. Sakai and T.Watanabe, 1992. A simple method for the assay of histidine decarboxylase activity in crude brain extracts regional distribution in various strains of mice. Biogenic Amines, 8: 315-322.

Oishi, R., 1988. Turnover of brain histamine and its changes by various drugs. Nippon Yakurigaku Zasshi, 92: 271-281.
PubMed  |  

Rodrigues, A.A, R. Leurs, T.S. Wu, G.D. Prell and C. Foged, 1996. Timmerman H [3H] thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex. Br. J. Pharmacol., 118: 2045-2052.
Direct Link  |  

Sakai, N., A. Sakurai, E. Sakurai, K. Yanai, K. Maeyama and T. Watanabe, 1992. Effects of the histamine H3 receptor ligands thioperamide and (R) α methylhistamine on histidine decarboxylase activity of mouse brain. Biochem. Biophys. Res. Commun., 185: 121-126.
Direct Link  |  

Sakai, N., K. Onodera, K. Maeyama, K. Yanai and T. Watanabe, 1991. Effects of thioperamide a histamine H3 receptor antagonist on locomotor activity and brain histamine content in mast cell deficient w/w mice. Life Sci., 48: 2397-2404.

Sakurai, E., E. Gunji, Y. Iizuka, N. Hikichi, K. Maeyama and T. Watanabe, 1994. The disposition of thioperamide a histamine H3 receptor antagonist in rats. J. Pharm. Pharmacol., 46: 209-212.
PubMed  |  

Taylor, S.J., A.D. Michel and G.J. Kilpatrick, 1992. In vivo occupancy of histamine H3 receptors by thioperamide and (R) α methylhistamine measured using histamine turnover and an Ex vivo labeling technique. Biochem. Pharmacol., 6: 1261-1267.

Vohora, D., S.N. Pal and K.K. Pillai, 2000. Thioperamide a selective histamine H3 receptor antagonist protects against PTZ induced seizures in mice. Life Sci., 66: 297-301.
CrossRef  |  

Watanabe, T., H. Nakamura, L.Y. Liang, A. Yamatodani and H. Wada, 1979. Partial purification and characterization of L histidine decarboxylase from fetal rats. Biochemi. Pharmacol., 28: 1149-1155.
PubMed  |  

Yamamoto, Y., T. Mochizuki, K.O. Mochizuki, A. Uno and A. Yamatodani, 1997. Thioperamide a histamine H3 receptor antagonist increases GABA release from the rat hypothalamus. Methods Find Exp. Clin. Pharmacol., 19: 289-298.
PubMed  |  

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