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Global Emergence of Nosocomial Gram-negative Pathogens Possessing Carbapenem-hydrolyzing ß-lactamases



Simona Bratu and John Quale
 
ABSTRACT

Carbapenem antibiotics are typically reserved for serious nosocomial infections. Several classes of ß-lactamases have emerged that possess carbapenem-hydrolyzing activity. Class A KPC-type ß-lactamases have recently emerged in Klebsiella pneumoniae isolates from the northeastern United States. Class D OXA-type ß-lactamases are typically found in Acinetobacter baumannii and Pseudomonas aeruginosa isolates from southern Europe. Class B metallo-ß-lactamases are also typically found in A. baumannii and P. aeruginosa; regions in the Far East and Europe have been especially affected by bacteria carrying these enzymes. Most nosocomial pathogens that possess a carbapenem-hydrolyzing ß-lactamases are frequently resistant to other classes of antibiotics, including aminoglycosides and fluoroquinolones. For infections caused by these highly resistant Gram-negative pathogens, polymyxin antibiotics are often administered, although concerns remain regarding their efficacy and toxicity.

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  How to cite this article:

Simona Bratu and John Quale , 2006. Global Emergence of Nosocomial Gram-negative Pathogens Possessing Carbapenem-hydrolyzing ß-lactamases. Journal of Biological Sciences, 6: 220-230.

DOI: 10.3923/jbs.2006.220.230

URL: https://scialert.net/abstract/?doi=jbs.2006.220.230

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