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Research Article

Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn

Ranajit Kumar Sutradhar , AKM Matior Rahman , Mesbahuddin Ahmad , Sitesh Chandra Bachar and Achinto Saha.
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A new flavonol glycoside, 3`-(3``,7``-dimethyl- 2``,6``-octadiene)-8-C-ß-D-glucosyl-kaempferol 3-O-ß-D-glucoside[1], isolated from Sida cordifolia Linn. was investigated for analgesic and anti-inflammatory activities in animal models. In the acetic acid induced writhing model, the drug at a dose of 25 and 50 mg kg-1 body weight showed statistically significant (p<0.0001) inhibition of writhing response of 25.12 and 52.30%, respectively. The drug also produced significant increase in the tail flick latency in a dose depended manner (r = 0.92) which were also statistically significant (p<0.0001). In carrageenan induced rat paw edema the compound produced 16.15 and 28.52% inhibition of paw edema at doses of 25 and 50 mg kg-1 body weight at the 3rd h of study.

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  How to cite this article:

Ranajit Kumar Sutradhar , AKM Matior Rahman , Mesbahuddin Ahmad , Sitesh Chandra Bachar and Achinto Saha. , 2006. Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn. Journal of Biological Sciences, 6: 160-163.

DOI: 10.3923/jbs.2006.160.163


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