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Journal of Biological Sciences

Year: 2006 | Volume: 6 | Issue: 6 | Page No.: 1141-1145
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Research Article

Antimicrobial and Gastroprotective Activities of Eucalyptus camaldulensis (Myrtaceae) Crude Extracts

B.A. Adeniyi, T.O. Lawal and S.B. Olaleye

ABSTRACT

The crude extracts of Eucalyptus camaldulensis were investigated for their in vitro antimicrobial and gastro-protective activities in albino rats. The antimicrobial activity was investigated by screening the crude plant extract for activity against Candida albicans and clinically isolated gentamycin resistant wound bacteria viz: Staphylococcus aureus UCH 2600, Escherichia coli UCH 2554, Pseudomonas aeruginosa UCH 2780 and Proteus mirabilis UCH 2773. These microorganisms were susceptible to the crude extracts at a 10 mg mL-1 concentration. The gastroprotective activity of the methanol extract of Eucalyptus camaldulensis (MEEC) was investigated in rats. Gastro protection was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. The Hcl/Ethanol mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric damage with ulcer index 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus camaldulensis leaf 200 and 1000 mg kg-1 orally for 1 h significantly reduced the formation of ulcer by the HCl/ethanol mixture with preventive ratios of 56 and 89%, respectively. Ranitidine afforded 92.5% protection. The results suggest that crude extracts of Eucalyptus camaldulensis has both antimicrobial and anti-ulcer properties.
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