Elham Haji-Sayyari
Department of Postodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Saeed
Department of Postodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
LiveDNA: Noukar
Mehran Mohseni
Department of Postodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Reza Fazeli
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Hossein Jamalifar
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Ebrahim Azizi
Department of Postodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
ABSTRACT
The potential mutagenicity of two Nickel-Chromium based alloys (Verabond II and Minalux) was determined using the Ames Salmonella/microsome test. According to ISO 6871-1 protocol, the alloys were mounted in an artificial saliva medium and incubated for 7 days at 37°C. Then aliquots were used to assess mutagenic effects of the released materials using Salmonella typhimurium strain TA 100 and the standard plate incorporation assay in the presence or absence of S9 fraction from rat liver. No mutagenic effects were detected for either alloys at 25, 50, 100 μL of test solutions. The S9 bioactivation also showed no mutagenic metabolite activities for these alloys. Therefore, it seems that both alloys have no mutagenic activity with or without bioactivation under the test conditions.
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How to cite this article
Elham Haji-Sayyari, Saeed, Mehran Mohseni, Mohammad Reza Fazeli, Hossein Jamalifar and Ebrahim Azizi, 2006. Mutagenic Potentials of Dental Alloys Using Ames Salmonella/microsome Test. Journal of Biological Sciences, 6: 106-108.
DOI: 10.3923/jbs.2006.106.108
URL: https://scialert.net/abstract/?doi=jbs.2006.106.108
DOI: 10.3923/jbs.2006.106.108
URL: https://scialert.net/abstract/?doi=jbs.2006.106.108
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