ABSTRACT
Ethephon (etherel) is a widely used as a plant growth promoter at low doses and a herbicide at high doses was evaluated for its toxigenic effects on albino mice. The study was assessed using 3 parameters, nucleic acids (DNA and RNA) concentrations in the liver and testis, protein content and cholinesterase activity in blood plasma. Ethephon was administrated to albino mice male with three doses level (1/4, 1/8 and 1/10 LD50 mg kg-1). Ethephon was found to reduce the DNA and RNA concentrations. Similar results were observed for the protein content and cholinesterase enzyme activity. The results showed that ethephon could be a mutagenic in mice. It is recommended that a great attention should be paid towards the mutagenicity of ethephon to animals and human.
PDF References Citation
How to cite this article
Nada H.A. Al-Twaty, 2006. Mutagenic Effects of Ethephon on Albino Mice. Journal of Biological Sciences, 6: 1041-1046.
DOI: 10.3923/jbs.2006.1041.1046
URL: https://scialert.net/abstract/?doi=jbs.2006.1041.1046
DOI: 10.3923/jbs.2006.1041.1046
URL: https://scialert.net/abstract/?doi=jbs.2006.1041.1046
REFERENCES
- Das, G.P., A.P. Shaik and K. Jamil, 2006. Estimation of apoptosis and necrosis caused by pesticides in vitro on human lymphocytes using DNA diffusion assay. Drug Chem. Toxicol., 29: 147-156.
PubMed - El-Mofty, M.M., S.A. Sakr, A.M. Rizk and E.A. Moussa, 1994. Carcinogenic effect of gibberellin A3 in Swiss albino mice. Nutr. Cancer, 21: 183-190.
PubMed - Marcano, L., I. Carruyo, A. Del Campo and X. Montiel, 2004. Cytotoxicity and mode of action of maleic hydrazide in root tips of Allium cepa L. Environ. Res., 94: 221-226.
CrossRefDirect Link - Jagannath, D.R., 1987. Mutagenicity test on ethephon base 250 in the Ames Salmonella/microsome reverse mutation assay. Unpublished report No. 10065-0-401 from Hazleton Laboratories America, Inc., 5518 Nicholson Lane, Suit 400, Kensington, Maryland 20895, USA. Submitted to WHO by Rhone-Poulenc Sector Agro., 14, 20, Rue Pierre Baizet, BP 9163- 69263Lyon Cedex 09, France.
- Pratt, I.S. and T. Barron, 2003. Regulatory recognition of indirect genotoxicity mechanisms in the European Union. Toxicol. Lett., 140-141: 53-62.
CrossRefDirect Link