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Pharmacokinetics of Amoxycillin in Camel

Mohammed H. Al-Nazawi

The disposition of amoxycillun following intravenous (IV) and oral administration in camel was studied. The kinetic behavior of the drug was best described by two compartment open model. The half-life of distribution was 3.6±0.36 min for IV and 15.3±1.9 min for oral dosing. The half-life of elimination was 69.3±2.6 min for IV and 80.0±3.4 min for oral dosing. The mean peak plasma concentration after oral administration was 2.11±8.3 μg mL-1 detected at 2 h after drug administration and the bioavailability was 23.3%.

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  How to cite this article:

Mohammed H. Al-Nazawi , 2005. Pharmacokinetics of Amoxycillin in Camel. Journal of Biological Sciences, 5: 149-152.

DOI: 10.3923/jbs.2005.149.152


Abdalla, M.A. and O. Abdalla, 1979. Morphometric observations on the kidney of the camel, Camelus dromedaries. J. Anat., 129: 45-50.
Direct Link  |  

Agerso, H. and C. Friis, 1998. Bioavalability of amoxycillin in pigs. J. Vet. Pharmacol. Therapeut., 21: 41-46.

Bennett, J.V., J.L. Brodie, E.J. Benner and W.M.M. Kirby, 1966. Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiol., 14: 170-177.
PubMed  |  Direct Link  |  

Comber, K.R., C.D. Osborne and R. Sutherland, 1975. Comparative effects of amoxicillin and ampicillin in the treatment of experimental mouse infections. Antimicrob. Agents Chemother., 7: 179-185.

Craigmill, A.L., M.A. Pass and S. Wetzlich, 1992. Comparative pharmacokinetics of amoxicillin administered intravenously to sheep and goats. J. Vet. Pharmacol. Therapeut., 15: 72-77.

Ensink, J.M., W.R. Klein, D.J. Mevius, A. Klarenbeck and A.G. Vulto, 1992. Bioavailability of oral penicillin in the horse a comparison of pivampicillin and amoxicillin. J. Vet. Pharmacol. Therapeut., 15: 221-230.

Eshelman, E.N. and D.A. Spyker, 1978. Pharmacokinetics of amoxicillin and ampicillin: Cross-over study of the effect of food. Antimicrob. Agents Chemother., 14: 539-543.

Gibaldi, M. and D. Perrier, 1982. Pharmacokinetics. 2nd Edn., Marcel Dekker Inc., New York, pp: 409-417.

Gilman, A.G., T.W. Rall, A.S. Neis and P. Taylor, 1991. The Pharmacological Basis of Therapeutics. 8th Edn., Pergamon Press, New York.

Hunter, P., G.N. Rolinson and D.A. Witting, 1973. Bactericidal effect of amoxycillin in vivo compared with ampicillin. Antimicrob. Agents Chemother., 4: 285-293.

Hyatt, J.M., P.S. Mckinnon, G.S. Zimmer and J.J. Schentag, 1995. The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Clin. Pharmacokinetics, 28: 143-160.
CrossRef  |  

Kirkwood, B.R., 1988. Essential of Medical Statistics. 1st Edn., Blackwell Scientific Publications, Oxford.

Knoppert, N.W., S.M. Nijmeijer and C.T.M. Vandum, 1988. Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick-borne fever infected dwarf goat. J. Vet. Pharmacol. Therapeut., 11: 135-144.

Kung, K. and M. Wanner, 1994. Bioavailability of different forms of amoxicillin administered orally in dogs. Vet. Record, 135: 552-554.
Direct Link  |  

Lennernas, H., L. Knutson, T. Knutson, A. Hussain, L. Lesko, T. Salmonson and G.L. Amidon, 2002. The effect of amiloride on the in vivo effective transport of amoxycillin in human jejunum: Experience from a regional perfusion technique. Eur. J. Pharm. Sci., 15: 271-277.
Direct Link  |  

Ratz, V., R. Maas, G. Semjen, A.S. van Miert and R.F. Witkamp, 1995. Oral bioavailability of sulphonamides in ruminants: A comparison between sulfamethoxazole, sulphatroxazole and sulphamerazine, using the dwarf goat as an animal model. Vet. Q., 17: 82-87.
Direct Link  |  

Rolinson, G.N., A.C. Macdonald and D.A. Wiilson, 1977. Bactterial action of β-lactam antibiotics and Escherichia coli with particular reference to ampicillin and amoxycillin. J. Antimicrob. Chemother., 3: 541-553.

Shoaf, S.E., W.S. Schwark and C.L. Guard, 1987. The effect of age and diet on sulfadiazine trimethoprim disposition following oral and subcutaneous administration to calves. J. Vet. Pharmacol. Therapeut., 10: 331-345.

Spyker, D.A., R.J. Rugloski, R.L. Vann and W.M. O`Brien, 1977. Pharmacokinetics of amoxicillin: Dose dependence after intravenous, oral and intramuscular administration. Antimicrob. Agents Chemother., 11: 132-141.

Sutherland, R. and G.N. Rolinson, 1970. α-Amino-p-hydroxybenzylpenicillin (BRL 2333): A new semisynthetic penicillin in vitro evaluation. Antimicrob. Agents Chemother., 1: 411-415.

Torres-Molina, F., J.E. Peris-Ribera, M.C. Garcia-Carbonell, J.C. Aristorena, L. Granero and J.M. Pla-Delfina, 1992. Nonlinearities in amoxicillin pharmacokinetics. Disposition studies in the rat. Biopharm. Drug Disposit., 13: 23-38.

Wesphal, J.F., J.H. Trouvin, A. Deslandes and C. Carbon, 1990. Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans. J. Pharmacol. Exp. Therapeut., 255: 312-317.
Direct Link  |  

Wesphal, J.F., J.H. Trouvin, A. Deslandes and C. Carbon, 1991. Reappraisal of amoxicillin absorption kinetics. J. Antimicrob. Chemother., 27: 647-654.

Wilson, R.T., 1984. The Camel. 1st Edn., Longman Group Ltd., London, pp: 69-77.

Wilson, W.D., M.S. Spensley, J.D. Baggot and S.K. Hietala, 1988. Pharmacokinetics and estimated bioavailability of amoxicillin in mares after intravenous, intramuscular and oral administration. Am. J. Vet. Res., 49: 1688-1694.

Woodhead, M.A., I.T. Macfarlane, J.S. Mccracken, D.S. Rose and R.D. Finch, 1987. Prospective study of the aetiology and outcome of pneumonia in the community. Lancet, 2: 671-674.

Yeoman, G.H., 1977. Microbiology and bioavailability of amoxicillin. Vet. Med. Small Anim. Clin., 72: 720-738.

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