ABSTRACT
The disposition of amoxycillun following intravenous (IV) and oral administration in camel was studied. The kinetic behavior of the drug was best described by two compartment open model. The half-life of distribution was 3.6±0.36 min for IV and 15.3±1.9 min for oral dosing. The half-life of elimination was 69.3±2.6 min for IV and 80.0±3.4 min for oral dosing. The mean peak plasma concentration after oral administration was 2.11±8.3 μg mL-1 detected at 2 h after drug administration and the bioavailability was 23.3%.
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Mohammed H. Al-Nazawi, 2005. Pharmacokinetics of Amoxycillin in Camel. Journal of Biological Sciences, 5: 149-152.
DOI: 10.3923/jbs.2005.149.152
URL: https://scialert.net/abstract/?doi=jbs.2005.149.152
DOI: 10.3923/jbs.2005.149.152
URL: https://scialert.net/abstract/?doi=jbs.2005.149.152
REFERENCES
- Bennett, J.V., J.L. Brodie, E.J. Benner and W.M.M. Kirby, 1966. Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiol., 14: 170-177.
PubMedDirect Link - Kung, K. and M. Wanner, 1994. Bioavailability of different forms of amoxicillin administered orally in dogs. Vet. Record, 135: 552-554.
Direct Link - Abdalla, M.A. and O. Abdalla, 1979. Morphometric observations on the kidney of the camel, Camelus dromedaries. J. Anat., 129: 45-50.
Direct Link - Ratz, V., R. Maas, G. Semjen, A.S. van Miert and R.F. Witkamp, 1995. Oral bioavailability of sulphonamides in ruminants: A comparison between sulfamethoxazole, sulphatroxazole and sulphamerazine, using the dwarf goat as an animal model. Vet. Q., 17: 82-87.
Direct Link - Wesphal, J.F., J.H. Trouvin, A. Deslandes and C. Carbon, 1990. Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans. J. Pharmacol. Exp. Therapeut., 255: 312-317.
Direct Link - Lennernas, H., L. Knutson, T. Knutson, A. Hussain, L. Lesko, T. Salmonson and G.L. Amidon, 2002. The effect of amiloride on the in vivo effective transport of amoxycillin in human jejunum: Experience from a regional perfusion technique. Eur. J. Pharm. Sci., 15: 271-277.
Direct Link - Hyatt, J.M., P.S. Mckinnon, G.S. Zimmer and J.J. Schentag, 1995. The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Clin. Pharmacokinetics, 28: 143-160.
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