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Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis

Tasneem Shams Shaikh , Yasmeen Faiz Kazi , Imtiaz Ahmed and Mohammad R.A. Malik

This study was undertaken to evaluate and understand the effect of Augmentin, Erythromycin and Ofloxacin against Bordetella pertussis (B. pertussis) in murine model. Mice (BALB/C) were challenged with highly infective dose (2.2x109 CFU mL-1) of B. pertussis and relatedness of pathophysiological responses, its intensity and the course was studied by monitoring the infection with mouse weight gain, temperature, induction of leukocytosis and lung score. Treatment was started giving first dose orally after an hour of infection, therapy was continued for six days. Antibiotics appeared to have provided benefit in decreasing the infection. Conclusively, Augmentin was found more effective than Erythromycin and Ofloxacin and indicated more persistent and potent efficacy in vivo.

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Tasneem Shams Shaikh , Yasmeen Faiz Kazi , Imtiaz Ahmed and Mohammad R.A. Malik , 2005. Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis. Journal of Biological Sciences, 5: 129-133.

DOI: 10.3923/jbs.2005.129.133


Altmeier, W.A. and E.M. Ayoub, 1977. Erythromycin prophylaxis for pertussis. Pediatrics, 59: 623-625.

Bass, J.W., 1983. Use of erythromycin in pertussis outbreaks. Pediatrics, 72: 748-749.
Direct Link  |  

Bass, J.W., J.B. Kothmeier, C.C Linnmann and H.D. Smith, 1969. Antimicrobial treatment of pertussis. J. Pediatr., 61: 224-230.

Bergeron, M.G., 1988. The future of new antibiotics including the quinolones. Can. Med. Assoc. J., 183: 35-42.
Direct Link  |  

CDC, 2002. Morbidity and mortality. Weekly Rep., 51: 616-618.

Collen D., 1993. Clavulanic Acid Therapeutic Drugs. Vol. 1, Churchil Livingstone, USA.

Comber, K.R., R.J. Boom and R. Sutherland, 1977. Comparative effects of amoxycillin and ampicillin on the morphology of E. coli in vivo and correlation with activity. Antimicrob. Agents Chemother., 12: 736-739.

Dutta, P., U. Mitra, S. Dutta, A. De, M.K. Chatergee and S.K. Bhatacharia, 2001. Ceftriaxone therapy in ciprofloxacin treatment failure typhoid fever in children. Indian J. Med. Res., 113: 210-213.
Direct Link  |  

Edmunds, W.J., M. Brisson, A. Melegaro and N.J. Gay, 2002. The potential cost-effectiveness of acellular pertussis booster vaccination in England and Wales. Vaccine, 20: 1316-1330.
CrossRef  |  Direct Link  |  

Elizabeth, H., R. Parton and A.C. Wardlaw, 1997. Differences in coughing and other responses to intrabronchial infection with Bordetella pertussis among strains of rats. Infect. Immun., 65: 4711-4717.
Direct Link  |  

Heininger, U., J.D. Cherry and K. Stehr, 2004. Serologic response and antibody-titer decay in adults with pertussis. Clin. Infect. Dis., 38: 591-594.
CrossRef  |  Direct Link  |  

Hoppe, J.E. and A. Haug, 1987. Antimicrobial susceptibility of Bordetella pertussis (part I). Infection, 16: 126-130.
CrossRef  |  Direct Link  |  

Lambert, H., 1979. Antimicrobial drugs in the treatment and prevention of pertussis. J. Antimicrob. Chemother., 5: 329-331.
CrossRef  |  Direct Link  |  

Long, S.S., C.J. Welkon and J.L. Clark, 1990. Widespread silent transmission of pertussis in families: Antibody correlates of infection and symptomatology. J. Infect. Dis., 161: 480-486.
CrossRef  |  Direct Link  |  

Muller, A.S., J. Leeuwenburg and D.S. Pratt, 1986. Pertussis: Epidemiology and control. Bull. World Health Organ., 64: 321-331.
Direct Link  |  

Pittman, M., 1970. Bordetella pertussis Bacterial and Host Factors in Pathogenasis and Prevention of Whooping Cough. In: Agents and Host Reactions, Mudd, S. (Ed.). W.B Saunders Co., Philadelphia, pp: 239-270.

Pittman, M., B.L. Furman and A.C. Wardlaw, 1980. Bordetella pertussis respiratory tract infection in the mouse: Pathophysiological responses. J. Infect. Dis., 142: 56-66.
CrossRef  |  Direct Link  |  

Rappuoli, R., M. Pizza, A. Podda, D.M. Magistris and L. Nencioni, 1991. Towards third generation of vaccines. Trend Biotechnol., 91: 232-238.

World Health Organization, 1998. Informal Consultation on Control of Pertussis with Whole Cell and Acellular Vaccines. World Health Organisation, Geneva.

Zak, O. and F. Kradofler, 1977. Activity CGP 9000 oral cephalosporin at sub MIC levels in experimental animals. Proceedings of 17th Omterscience Conference on Antimicrobial Agents and Chemotherapy, No. 4. American Society for Microbiology. Washington, DC.

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