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Journal of Biological Sciences

Year: 2004 | Volume: 4 | Issue: 4 | Page No.: 463-469
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Research Article

Evaluation of Hepatoprotective Effects of Raphanas sativus L.

Rifat-uz-Zaman and Mobasher Ahmad

ABSTRACT

The hepatoprotective study of Raphanas sativus fruit powder (RS), it`s aqueous (RS-A) and ethanolic (RS-E) extracts was performed on rabbits. The fruit powder (0.5-1.5 g kg-1 of body weight) tested in cadmium chloride (Cd) treated rabbits. The effects of aqueous and ethanolic extracts of RS (equivalent to 1.5 g kg-1 of body weight) were also noted (with Cd). Both RS-A and RS-E significantly decreased the total bilirubin level and activity of enzymes i.e. ALT and AP in serum of Cd-treated rabbits. RS-E declined the serum ALT activity more effectively than the RS or RS-A in the treated animals. The lowering effect of the RS was more marked as compared to its extracts on the serum AP and total bilirubin level in the treated rabbits. Anti-inflammatory/anti-apoptosis activity of RS may be responsible for this hepatoprotective activity.
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