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Research Article

Anti Yeast Activity of Some Plants Used in Traditional Herbal-medicine of Iran

G.H. Shahidi Bonjar
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This is the first report showing the anti-yeast activities of different Iranian plants. Plants used in herbal-medicine were collected from South-East regions of Iran. Methanolic extracts were prepared and evaluated in Agar well-diffusion test against three yeast species of Saccharomyces cerevisiae, Candida albicans and C. utilis. From 48 plant species in 34 families, 26 species in 20 families showed inhibitory effect at least against one yeast species at 20 mg ml ha-1 . Plants with high anti-yeast activity included Alpinia officinarum, Chrozophora verbasafalia , Cinnamomum zeylanicum, Dianthus coryophyllus, Helleborus nigra, Heracleum persicum, Myrtus communis, Terminalia chebula and Trachysermum copticum which were effective mostly against C. albicans and C. utilis. No plant showed high level of activity against S. cerevisiae. The lowest MIC was observed in M. communis and T. chebula as 0.31 mg ml ha-1 . Active extracts retained their activity at room temperature in both DMSO: methanol (1:1, v/v) solvent and lyophilized state up to 18 months.

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  How to cite this article:

G.H. Shahidi Bonjar , 2004. Anti Yeast Activity of Some Plants Used in Traditional Herbal-medicine of Iran. Journal of Biological Sciences, 4: 212-215.

DOI: 10.3923/jbs.2004.212.215



  1. Bennet, R.N. and R.M. Wallsgrove, 1994. Transley review no 72: Secondary metabolites in plant defence mechanism. New Phytologist, 127: 617-633.
    Direct Link  |  

  2. Osbourn, A.E., 1996. Preformed antimicrobial compounds and plant defense against fungal attack. Plant Cell, 8: 1821-1831.
    CrossRef  |  PubMed  |  Direct Link  |  

  3. Pharm, M.E.K., 2001. Antifungal resistance among Candida species. Pharmacother.: J. Hum. Pharmacol. Drug Therapy, 21: 124S-132S.
    CrossRef  |  PubMed  |  Direct Link  |  

  4. Mansouri, S., 1999. Inhibition of Staphylococcus aureus mediated by Iranian plants. Pharma. Biol., 37: 375-377.

  5. Mansouri, S., A. Foroumadi, T. Ghanei and A.G. Najar, 2001. Antibacterial activity of the crude extracts and fractionated constituents of Myrtus communis. Pharm. Biol., 39: 399-401.
    Direct Link  |  

  6. Cavin, A., W. Dyatmyko and K. Hostettmann, 1999. Screening of Indonesian plants for antifungal and free radical scavenging actives. Pharma. Biol., 37: 260-268.

  7. Crockett, C.O., E. Guede-Guina, O. Pugh, T.L. Vangah-Manda, T.T. Robinson, J.O. Olubacheiro and R.F. Ochillo, 1992. Cassia alata and the preclinical search for therapeutic agents for the treatment of opportunistic infection in AIDs patients. Cell Mol. Biol., 38: 799-802.

  8. Aucott, J.N., J. Fayen, H. Grossnicklas, A. Morrissey, M.M. Lederman and R.A. Salata, 1990. Invasive infection with Saccharomyces cerevisiae: Report of three cases and review. Rev. Infect. Dis., 12: 406-411.

  9. Goff, D.A., S.L. Koletar, W.J. Buesching, J. Barnishan and R.J. Fass, 1995. Isolation of fluconazole-resistant Candida albicans from human immunodeficiency virus-negative patients never treated with azoles. Clin. Infect. Dis., 20: 77-83.
    Direct Link  |  

  10. Nolte, F.S., T. Parkinson and D.J. Falconer, 1997. Isolation and characterization of fluconazole-and amphotericin B-resistant Candida albicans from blood of two patients with leukemia. Antimicrob. Agents Chemother., 41: 196-199.
    Direct Link  |  

  11. Kieren, A.M., C.N. Lyons, T. Rustad, R.A. Bowden and T.C. White, 1998. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Antimicrob. Agents Chemother., 42: 2584-2589.
    Direct Link  |  

  12. WHO, 2001. WHO Global Strategy for Containment of Antimicrobial Resistance. WHO Publication, Geneva

  13. Forbes, B.A., D.F. Sahm, A.S. Weissfeld and E.A. Trevino, 1990. Methods for Testing Antimicrobial Effectiveness. In: Bailey Scott's Diagnostic Microbiology, Baron, E.J., L.R. Peterson and S.M. Finegold (Eds.). Mosby Co., St Louis, Missouri, MI., pp: 171-194

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