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Quality of Marketed Metronidazole Preparations in Bangladesh- An Analytical Overview



F. Ahmed , A.K. Das , U.K. Karmakar , T. Khaleque and M.C. Shill
 
ABSTRACT

In Bangladesh, about 100 pharmaceutical companies are manufacturing about 160 products of metronidazole. Of them 40 products (30 tablet and 10 suspension) were analyzed. Potency of the selected products were assayed spectrophotometrically and their various physical parameters (color variation, thickness, weight variation, hardness, friability, disintegration time, dissolution rate, pH of suspension) were analyzed according to the official (BP/USP) pharmacopoeial methods to evaluate their quality. The results showed that 26 brands of tablets meet the BP specification of potency and the remaining 4 were less potent. 8 brands of suspensions meet the BP specification of potency and the remaining 2 were less potent. All brands tested, showed a good result for color variation, thickness, hardness, disintegration time and dissolution rate. 2 brands failed to meet the weight variation test specification. It is evident from the study that most of the brands tested showed good results but a few of them failed to meet the specification.

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  How to cite this article:

F. Ahmed , A.K. Das , U.K. Karmakar , T. Khaleque and M.C. Shill , 2003. Quality of Marketed Metronidazole Preparations in Bangladesh- An Analytical Overview. Journal of Biological Sciences, 3: 940-950.

DOI: 10.3923/jbs.2003.940.950

URL: https://scialert.net/abstract/?doi=jbs.2003.940.950

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