Subscribe Now Subscribe Today
Research Article

Toxic Effect of a Synthetic Pyrethroid Insecticide (Cypermethrin) on Blood Cells of Rainbow Trout (Oncorhynchus mykiss, Walbaum)

M. Nuri Cakmak and Asiye Girgin
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

In this study, haematological parameters of rainbow trout, Oncorhynchus mykiss were examined to determine if cypermethrin influenced the measurements. The results indicated that the haematological changes were more evident in fish exposed to cypermethrin. Levels of haematocrit, haemoglobin, leukocyte, red blood cells and MCHC decreased with increasing cypermethrin concentrations (p<0.01) but MCV level increased (p<0.01) and MCH level was not affected (p>0.05) with exposure of different cypermethrin concentration. There was also statistically significant differences in the mean levels of blood parameters of fish exposed to different cypermethrin concentrations (p<0.05).

Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

  How to cite this article:

M. Nuri Cakmak and Asiye Girgin , 2003. Toxic Effect of a Synthetic Pyrethroid Insecticide (Cypermethrin) on Blood Cells of Rainbow Trout (Oncorhynchus mykiss, Walbaum). Journal of Biological Sciences, 3: 694-698.

DOI: 10.3923/jbs.2003.694.698


1:  Anees, M.A., 1978. Haematological abnormalities in a fresh water teleost Channa punctatus exposed to sublethal and chronic levels of three organophosphorus insecticides. Int. J. Ecol. Environ. Sci., 4: 53-60.

2:  Bradbury, S.P. and J.R. Coats, 1989. Comparative toxicology of the pyrethroid insecticides. Rev. Environ. Contamin. Toxicol., 108: 133-177.

3:  Casida, J.E., D.W. Gammon, A.H. Glickman and L.J. Lawrence, 1983. Mechanisms of selective action of pyrethroid insecticides. Annu. Rev. Pharmacol. Toxicol., 23: 413-438.
CrossRef  |  

4:  Cengiz, E.I. and E. Unlu, 2002. Histopathological changes in the gills of mosquitofish. Gambusia affinis exposed to endosulfan. Bull. Environ. Contam. Toxicol., 68: 290-296.
CrossRef  |  PubMed  |  

5:  Coats, J.R. and N.L.O.D. Jeffery, 1979. Toxicity of four synthetic pyrethroid insecticides to Rainbow trout. Bull. Environ. Contamin. Toxicol., 23: 250-255.
CrossRef  |  

6:  Desaiah, D., K.L. Cutkomp, E.V. Vea and R.B. Koach, 1975. The effect of pyrethroids on ATPases of insects and fish. Gene. Pharmacol., 6: 31-34.

7:  Dorucu, M. and A. Girgin, 2001. The effects of cypermethrin on some haematological parameters of Cyprinus carpio. Aquac. Int., 9: 183-187.
CrossRef  |  

8:  Edwards, R., P. Millburn and D.H. Hudson, 1986. Comparative toxicology of cis-cypermethrin in rainbow trout, frog, mouse and quail. Toxicol. Applied Pharmacol., 84: 512-522.

9:  Edwards, R., P. Millburn and D.H. Hudson, 1987. The toxicity and metabolism of the pyrethroids cis-and trans-cypermethrin in rainbow trout, Salmo gairdneri. Xenobiotica, 17: 1175-1193.

10:  Eells, J.T., J.F. Rasmussen, P.A. Bandettini and J.F. Propp, 1993. Differences in the neuroexcitatory actions of pyrethroid insecticides and sodium channel-specific neurotoxins in rat and trout brain synaptosomes. Toxicol. Applied Pharmacol., 123: 107-119.

11:  Eshleman, A.J. and T.F. Murray, 1991. Pyrethroid insecticides indirectly inhibit GABA-dependent 36Cl-influx in synaptoneurosomes from the trout brain. Neuropharmacol., 30: 1333-1341.

12:  Khan, N.Y., 1983. An assessment of the hazard of synthetic pyrethroid, insecticides to fish and fish habitat. Pesticide Chem. Human Walfare Environ., 3: 437-450.

13:  Krishan, A.G. and V. Garg, 1981. 2-3-4-triaminoazobenzene induced haematobiochemical anomalies in fish, Channa punctatus. Bull. Environ. Contam. Toxicol., 26: 136-141.

14:  Martinez, F.J., M.P. Garcia-Riera, M. Canteras, J. de Costa and S. Zamora, 1994. Blood parameters in rainbow trout (Oncorhynchus mykiss): Smiltanneous inflluence of various factors. Comp. Biochem. Physiol., 101: 95-100.

15:  Morgan, D.P., E.M. Stockdale, R.J. Roberts and H.W. Walter, 1980. Anemia associated with exposure to lindane. Arch. Environ. Health, 35: 307-310.

16:  Moss, J.A. and D.E. Hathway, 1964. Transport of organic compounds in the mammal partition of Dieldrin and Telodrin between the cellular components and proteins of blood. Biochem. J., 91: 384-393.
Direct Link  |  

17:  Shires, S.W., 1985. Toxicity of a new pyretroid insecticide, WL85871, to rainbow trout. Bull. Environ. Contam. Toxicol., 34: 134-137.

18:  Singh, A. and R.A. Agarwal, 1993. Effect of cypermethrin on lactate and succinic dehydrogenase and cytochrome oxidase of snail and fish. Bull. Environ. Contam. Toxicol., 51: 445-452.

19:  Sivaprasad, R.K., C.S. Chetty and D. Desaiah, 1984. In vitro effects of pyrethroids on rat brain and liver ATPase activities. J. Toxicol. Environ. Health, 14: 257-265.

20:  Elliott, M., 1977. Synthetic Pyrethroids. American Chemical Society, Washington, pp: 1-28.

21:  Fowler, J. and L. Cohen, 1992. Practical Statistics for Field Biology. John Wiley and Sons, New York, USA., pp: 227.

22:  Kocabatmaz, M. and G. Ekingen, 1984. The standardization of blood sampling and haematological methods in different species of fish Doga Bilim Dergisi. J. Nat. Sci., 2: 149-157.

©  2020 Science Alert. All Rights Reserved