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Anionic Hydrogels for Controlled Release of Transdermal Drug



Bashir Ahmad , Shumaila Bashir , Muhammad Nisar and M.B.Huglin
 
ABSTRACT

Anionic hydrogels, using Azo-iso butyronitrile as cross linker, with varying ionic moieties were prepared from N vinyl-2-Pyrrolidone/Methylene Succinic acid/water by heating them at different temperatures for different interval of times. Swelling/drug loading sensitivity with pH and ionic strength of the medium for these hydrogels were investigated. The results anticipate that hydrogels in the ratio of VP/IA 90:10 can be used for local therapeutic Transdermal drug delivery application of cationic, antifungal terbinafine hydrochloride (TER-HCl) in the concentration range of <100 mg ml G 1. In vitro studies in different buffer solutions indicated that pH and IA contents are two basic parameters which affect the release behaviour of the hydrogels.

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  How to cite this article:

Bashir Ahmad , Shumaila Bashir , Muhammad Nisar and M.B.Huglin , 2003. Anionic Hydrogels for Controlled Release of Transdermal Drug. Journal of Biological Sciences, 3: 298-304.

DOI: 10.3923/jbs.2003.298.304

URL: https://scialert.net/abstract/?doi=jbs.2003.298.304

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