Bashir Ahmad
Department of Pharmacy, University of Peshawar, 25120, NWFP. Pakistan
Shumaila Bashir
Department of Pharmacy, University of Peshawar, 25120, NWFP. Pakistan
Muhammad Nisar
Department of Pharmacy, University of Peshawar, 25120, NWFP. Pakistan
M.B.Huglin
Institute of Material Research and Chemistry, Cockcroft Building, Salford University, M5 4WT England
ABSTRACT
Anionic hydrogels, using Azo-iso butyronitrile as cross linker, with varying ionic moieties were prepared from N vinyl-2-Pyrrolidone/Methylene Succinic acid/water by heating them at different temperatures for different interval of times. Swelling/drug loading sensitivity with pH and ionic strength of the medium for these hydrogels were investigated. The results anticipate that hydrogels in the ratio of VP/IA 90:10 can be used for local therapeutic Transdermal drug delivery application of cationic, antifungal terbinafine hydrochloride (TER-HCl) in the concentration range of <100 mg ml G 1. In vitro studies in different buffer solutions indicated that pH and IA contents are two basic parameters which affect the release behaviour of the hydrogels.
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How to cite this article
Bashir Ahmad, Shumaila Bashir, Muhammad Nisar and M.B.Huglin, 2003. Anionic Hydrogels for Controlled Release of Transdermal Drug. Journal of Biological Sciences, 3: 298-304.
DOI: 10.3923/jbs.2003.298.304
URL: https://scialert.net/abstract/?doi=jbs.2003.298.304
DOI: 10.3923/jbs.2003.298.304
URL: https://scialert.net/abstract/?doi=jbs.2003.298.304
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