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Research Article

Comparison of Induced Effect of Pyrethroid (Cypermethrin) with Organophosphate (Malathion) on GOT and GPT in Liver, Kidney and Brain of Calotes versicolor Daudin (Agamidae: Reptilia)

Muhammad Zaheer Khan and Farina Fatima

Experiments were carried out to find the induced effect of pyrethroid (cypermethrin) and organophosphate (malathion) was observed on GOT and GPT of Calotes versicolor Daudin. Two different concentrations 0.1 and 1% were used. In the surviving lizards GOT and GPT activities were estimated, in liver, kidney and brain. These activities were decrease of GOT upto 33 and 37% in liver, 23 and 66% in kidney and 38 and 61% in brain under the effect of cypermethrin. In the case of malathion the decrease of GOT activity was found as 26 and 33% in liver, 30 and 44% in kidney and 28 and 46% in brain. Under the effect of cypermethrin an average decrease in GPT upto 23 and 31% in liver, 26 and 42% in kidney and 2.47 and 11% in brain, while under the treatment of malathion the decrease of GPT activity was found as 21 and 23% in liver, 25 and 27% in kidney and 11 and 20% in brain, respectively.

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Muhammad Zaheer Khan and Farina Fatima , 2002. Comparison of Induced Effect of Pyrethroid (Cypermethrin) with Organophosphate (Malathion) on GOT and GPT in Liver, Kidney and Brain of Calotes versicolor Daudin (Agamidae: Reptilia). Journal of Biological Sciences, 2: 408-410.

DOI: 10.3923/jbs.2002.408.410


Azmi, M.A., 1992. Determination of DDT, malathion and solfac (cyfluthrin 10%) resistance in culicine mosquitoes of Karachi region and their effect on proteinic and enzymatic pattern. Ph.D. Thesis, Department of Zoology, University of Karachi, Karachi, Pakistan.

Azmi, M.A., S. Jahan, S.N.H. Naqvi, R. Tabassum, M.F. Khan and K. Akhtar, 1999. Effect of tetranortriterpenoids (neem products SDS) and deltramethrin (pyrethroid) on phosphomonoesterases activity in Cyprinus carpio (common carp). Nat. Acad. Sci. Lett., 22: 130-134.

Bishop, C.A., B. Collin, P. Mineau, N.M. Burgees, W.F. Red and C. Risley, 2000. Reproduction activity of nesting birds in pesticide sprayed apple orchards in Southern Ontario, Canada. Environ. Toxicol. Chem., 19: 588-599.

Burn, J.D. and F.A. Leighton, 1996. Further studies of brain cholinesterase: Cholinergic receptors rations in the diagnosis of acute lethal poisoning of birds by anticholinesterase pesticides. J. Wildl. Dis., 32: 216-224.

Clark Jr., D.R., E.L. Flickinger, D.H. White, R.L. Hothem and A.A. Belisle, 1995. Dicofol and DDT residues in lizard carcasses and bird eggs from Texas, Florida and California. Bull. Environ. Contam. Toxicol., 54: 817-824.
CrossRef  |  Direct Link  |  

George, T.L., L.C. McEwen and B.E. Peterson, 1995. Effects of grasshopper control programs on rangeland breeding birds populations. J. Range Manag., 48: 336-342.

Ghalib, S.A., H. Rehman, F. Iffat and S.A. Husnain, 1979. A checklist of reptiles of Pakistan. Rec. Zool. Surv. Pak., 8: 37-60.

Grue, C.E., W.J. Fleming, D.G. Busby and E.F. Hill, 1983. Assessing hazards of organophosphate pesticide to wildlife. Trans. N. Am. Wildl. Nat. Res. Confr., 48: 200-200.

Henny, C.J., E.J. Kolbe, E.F. Hill and L.J. Blus, 1987. Case histories of Bald Eagles and other raptors killed by organophosphorus insecticides topically applied to livestock. J. Wildl. Dis., 23: 292-295.

Hill, E.F., 1989. Sex and storgae effect cholinesterase activity in blood plasma of Japan quail. J. Wildl. Dis., 25: 580-585.

Hilton-Taylor, C., 2000. IUCN Red List of Threatened Species. IUCN, Gland, Switzerland and Cambridge, UK., pp: 18-61.

Kegley, S., L. Neumeister and T. Martin, 1999. Disrupting the Balance: Ecological Impacts of Pesticides in California. Pesticide Action Network, California, pp: 99.

Khan, M.Z., R. Tabassum, S.N.H. Naqvi, M.A. Azmi and I. Ahmad, 1999. Effect of neem extracts (RB-a and RB-b) and pyrethroid (cypermethrin) on enzymatic pattern of late 3rd instar larvae of Aedes aegypti of PCSIR strain, gulshan-e-iqbal and organi town stations. Bull. Pure Applied Sci., 18: 107-111.

Khan, M.Z., S.N.H. Naqvi, M.F. Khan, T. Rahila, I. Ahmad and F. Farina, 2002. Induced effect of Biosal on GOT and GPT in wildlife species of Agama lizard calotes versicolor. Pak. J. Biol. Sci., 4: 611-612.

O`Hara, T.M., M.M. Krahn, D. Boyd, P.R. Becker and L.M. Philo, 1999. Organochlorine contaminant levels in Eskimo harvested bowhead whales of Arctic Alaska. J. Wildl. Dis., 35: 741-752.
PubMed  |  Direct Link  |  

Parsons, K.C., A.C. Matz, M.J. Hooper and M.A. Pokras, 2000. Monitorinh eading bird exposure to agricultural chemicals using serum cholinesterase activity. Environ. Toxicol. Chem., 19: 1317-1323.

Rehman, R. and F. Iffat, 1997. A revised checklist of reptiles of Pakistan. Rec. Zool. Sur. Pak., 8: 63-70.

Reitman, S. and S. Frankel, 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28: 56-63.
CrossRef  |  PubMed  |  Direct Link  |  

Richards, S.M., T.A. Anderson, M.J. Hooper, S.T. McMurry and S.B. Wal et al., 2000. European starling nesting response to chlorpyrifos exposure in a corn agroecosystem. Toxicol. Environ. Chem., 75: 215-234.

Rogner, M., 1997. Lizards Husbandry and Reproduction in the Vivarium: Geckoes, Flap-Footed Lizards, Agamas, Chameleons and Lguanas. Krieger Publication Co., Florida, USA.

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