Submit Manuscript

Journal of Biological Sciences

Year: 2001 | Volume: 1 | Issue: 11 | Page No.: 1066-1068
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Research Article

Renal Lesions Induced by Pyrethroid Inhalation in Albino Rats

S. A. Sakr, H. A. Mahran and Y. A. Okdah

ABSTRACT

The effect of pyrethroid inhalation was studied on the kidney of Albino rats. The results revealed that animals inhaled tetramethrin for 15 days showed a significant increase in serum creatinine and blood urea nitrogen. Histological examination of the kidney of treated animals indicated marked symptoms of renal tissues impairment. The renal tubules lost their characteristic appearance and their linning epithelial cells appeared with cytoplasmic vacuolation. The glomeruli were degenerated and the renal blood vessels were congested. The intertubular spaces were infiltrated by inflammatory leucocytic cells. The magnitude of these changes was time-dependent, being more prominent after 15 days of treatment.
PDF References Citation

Search

REFERENCES

  1. Abdeen, A.M., T.A. Amer, E.M. El-Habibi and E.M. Kamel, 1994. Hitological and histochemical studies on the effect of fenvalerate insecticide on some organs of albino mice. J. Union Arab Biol., 21: 129-166.
  2. Abdel-Rahman, M.F. and T.Z. Zaki, 1992. Histopathological and histochemical effects of sevin on the renal and hepatic tissues of mice. J. Egypt. Ger. Soc. Zool., 8: 115-126.
  3. Abou-Zaid, F.A. and R.M. El-Balshy, 1995. Toxic effect of Ezalo, a synthetic pyrethroid on liver, kidney and lung of newly born mice. J. Union Arab Biol., 4: 235-264.
  4. Abu-El-Zahab, H.S., M.M. Amer, R. Awadallah, W.E. Abdel-Aal and Z.A. El-Khyat, 1993. Physiological and histopathological studies on long-term inhalation of adult albino rats to pyrethroids. III. Serum proteins, enzymes, creatinine and urea nitrogen. J. Egypt. Ger. Soc. Zool., 11: 311-334.
  5. Casida, J.E., 1973. Pyrethrum: The Natural Insecticide. Academic Press, New York.
  6. Couser, W.G., 1988. Rapidly progressive glomerulonephritis: Classification, pathogenic mechanisms and therapy. Am. J. Kidney Dis., 11: 449-464.
    PubMedDirect Link
  7. El-Banhawy, M.A., A. Mahmoud, S.A. Gaber, A.M. Mostaffa, 2000. Histopathological studies on the liver of adult and embryonic stages of mice under the effect of Ezalo insecticide. J. Egypt. Ger. Soc. Zool., 32: 89-105.
  8. Hurket, P.C., 1978. Some histological and histochemical studies in rabbit Oryctolagus cuniculus during subchronic administration of dieldrin. Indian J. Exp. Biol., 16: 716-719.
    PubMedDirect Link
  9. Kulkarni, S. and M.A. Hodgson, 1980. Effect of pyrethroids on rat liver Atpase activities. J. Toxicol. Environ. Health, 14: 257-266.
  10. McLaughlin, G.A., 1973. History of Pyrethrum. In: Apyrethrum: The Natural Insecticide, Casida, J.E. (Ed.). Academic Press, New York and London.
  11. Mohamed, Z.A., 1988. Changes in rat blood profile and blood chemistry after repeated dermal application of fenvalerarte and decamethrin. Egypt. J. Food Sci., 16: 79-86.
  12. Parker, C.M., H.C. Wimberly, A.S. Lam, T.H. Gardiner and G.A. van Glder, 1986. Subchronic feeding study of decarboxy fenvalerate in rats. J. Toxicol. Environ. Health, 18: 77-90.
  13. Sakr, S.A. and A.E. Azab, 2001. Effect of pyrethroid inhalation on the testis of albino rat. Pak. J. Biol. Sci., 4: 498-500.
    CrossRefDirect Link
  14. Sakr, S.A., 1999. Pyrethroid inhalation-induced hepatotoxicity in albino rats. Oxford Res. Forum J., 1: 27-31.
  15. Seki, T., S. Ito, H. Adachi, K. Yoshioka, S. Hosokawa, A. Yoshitake, J. Miyamoto and Y. Kurata, 1987. One-year chronic dietary toxicity study of DDT80 Prallethrin in rats. J. Toxicol. Sci., 12: 397-428.
  16. Stevens, A. and J. Lowe, 1992. Histology. Gower Medical Publishing, London and New York.

Search

Leave a Comment

Your email address will not be published. Required fields are marked *