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Research Article

Survival Probability of Sickle Cell Patients with Respect to HbF Levels

Jean M. Tchuenche and Wuraola A. Shokunbi
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Sickle Cell Anaemia (SCA) constitutes a factor in the health of mankind. One of the regulating agents concealed in the mortality factors of SCA sufferers is their level or quantity of Foetal Haemoglobin. This study proposes a function which relatively describes the chance of survival of SCA patients in respect to their Foetal Haemoglobin levels. It is observed that survival increases as the level of foetal haeoglobin increases, decreases as age increases and this depicts the real life scenario. These are shown graphically.

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  How to cite this article:

Jean M. Tchuenche and Wuraola A. Shokunbi , 2006. Survival Probability of Sickle Cell Patients with Respect to HbF Levels. Journal of Applied Sciences, 6: 2804-2808.

DOI: 10.3923/jas.2006.2804.2808


1:  Alderson, M., 1976. An Introduction to Epidemiology. The Macmillan Press, UK.

2:  Clendennen, G.W. and L. Lwanda, 2003. David Livingstone and Southern Africa's first accorded cases of sickle cell anaemia. J. R. Coll. Physicians Edinb., 33: 21-28.
Direct Link  |  

3:  Dean, J. and A.N. Schechter, 1978. Molecular and Cellular base of therapeutic approaches. New Engl. J. Med., 299: 752-762.

4:  Emmel, V.E., 1917. A study of the erythrocytes in a case of severe anaemia with elongated and sickle-shaped red blood corpuscules. Arch. Int. Med., 20: 586-598.

5:  Herrick, J.B., 1904. The practical value of blood examinations. Illinois Med. J., 6: 619-621.

6:  Herrick, J.B., 1910. Peculiar elongated and sickle-shaped red blood corpuscules. Arch. Int. Med., 6: 517-521.

7:  King, R.C., 1965. Genetics. Oxford University Press, NewYork, pp: 237-240.

8:  Kotila, T.R., A.A. Adeyemo, F.M. Abbiyesuku and W.A. Shokunbi, 2000. Betke's and elution methods in estimation of haemoglobin F in sickle cell anaemia. East Afr. J., 77: 40-43.

9:  Mason, V.R., 1922. Sickle cell anaemia. J. Am. Med. Assoc., 79: 1318-1320.

10:  MacKendrick, A.G., 1926. Application of Mathematics to medical problems. Proc. Edinburgh Math. Soc., 44: 98-130.

11:  Odenheimer, D.J., C.F. Whitten and D.A. Ruckmayel., 1984. Stability over time of haematological variables in 197 children with SCA. Am. J. Med. Genet., 18: 461-470.

12:  Platt, O.S., D.J. Brambilla, W.F. Rosse, P.F. Milner, O. Castro, M.H. Steinberg and P.P. Klug, 1994. Mortality in sickle cell disease-Life expectancy and risk factors for early death. N. Engl. J. Med., 330: 1639-1644.
Direct Link  |  

13:  Savitt, T.L., 1997. The second reported case of sickle cell anemia charlottesville, Virginia, 1911. Virginia Med. Q., 124: 84-92.

14:  Serjeant, G.R., 2001. The emerging understanding of sickle cell anaemia. Br. J. Haematol., 112: 3-18.
CrossRef  |  

15:  Singer, K., A.I. Cheriff and L. Singer, 1951. Studies on abnormal haemoglobin I. Their demonstration in SCA and other haematologic disorders by means of Alkali denaturation. Blood, 6: 413-413.

16:  Steinberg, M.H., 1999. Management of sickle cell disease. New Engl. J. Med., 340: 1021-1030.
CrossRef  |  Direct Link  |  

17:  Tchuenche, J.M., 2002. Mathematical population dynamics of sickle cell anaemia, a genetically transmitted disease. Ph.D. Thesis, Fac. Sci., University of Ibadan.

18:  Tchuenche, J.M., 2003. A note on the MacKendrick Von foerster type mode: l in a population with an additional structure. Int. J. Math. Educ. Sci. Technol., 34: 463-470.

19:  Tchuenche, J.M., 2005. The effects of migration on the transmission dynamics of sickle-cell anaemia. Mediterranean J. Math., 2: 357-365.

20:  Washburn, R.E., 1911. Peculiar elongated and sickle-shaped red blood corpuscules in a case of severe anaemia. Virginia Med. Semi-Monthly, 15: 490-493.

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